Hirudin 蛋白, Poecilobdella viridis (P. pastoris)

Hirudin Protein, a powerful thrombin-specific protease inhibitor, forms a stable non-covalent complex with alpha-thrombin, effectively preventing fibrinogen cleavage. This interaction underscores hirudin's critical role in regulating key coagulation cascade steps. Its specific thrombin inhibition emphasizes hirudin's significance as a therapeutic agent, particularly for precise blood clotting regulation. Hirudin Protein, Poecilobdella viridis (P. pastoris) is the recombinant Hirudin protein, expressed by P. pastoris , with tag free. The total length of Hirudin Protein, Poecilobdella viridis (P. pastoris) is 63 a.a., with molecular weight of ~6.7 kDa.

水蛭素蛋白作为一种有效的凝血酶特异性蛋白酶抑制剂而出现，展示了其与 α-凝血酶形成稳定的非共价复合物的能力。这种相互作用导致α-凝血酶裂解纤维蛋白原的能力有效消除，强调了水蛭素在调节凝血级联关键步骤中的关键作用。水蛭素对凝血酶的特异性和靶向抑制凸显了其作为治疗剂的重要性，特别是在精确调节血液凝固至关重要的情况下。

The biological activity is determined by chromogenic assay, 1 unit is defined as the amount of Hirudin that neutralizes 1 unit of the WHO preparation 89/588 of thrombin. The specific activity is no less than 14,000 ATU/mg protein.

Others

P. pastoris

Tag Free

P84590 (V1-L63)

/

VVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPGPQSHNDGDFEEPEEYL

Approximately 6.7 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PBS, pH 7.0, containing 2 % mannitol.

<1 EU/μg; determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.