HNRNPA2B1 蛋白, Human (His-B2M)

Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (His-B2M) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-6*His, B2M labeled tag. The total length of HNRNPA2B1 Protein, Human (His-B2M) is 249 a.a., with molecular weight of ~42.4 kDa.

Heterogeneous nuclear ribonucleoproteins A2/B1 属于广泛表达的核不均一核糖核蛋白(hnRNPs)的A/B亚家族。Heterogeneous nuclear ribonucleoproteins A2/B1 是RNA结合蛋白，它们与核内不均一核糖核酸(hnRNA)复合。Heterogeneous nuclear ribonucleoproteins A2/B1 与核内前体mRNA相关，并似乎影响前体mRNA加工及mRNA代谢和转运的其他方面。Heterogeneous nuclear ribonucleoproteins A2/B1 具有不同的核酸结合特性。Heterogeneous nuclear ribonucleoproteins A2/B1 有两个与rna结合的准rrm结构域重复。Heterogeneous nuclear ribonucleoproteins A2/B1 已被描述产生两种可选择性剪接的转录变异体，编码不同的亚型^{[1][2][3][4][5]}。

Human

E. coli

N-6*His;B2M

I6L957 (M1-Q249)

/

MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEDLEVAILEVAPVMEEEEEDMVVEDLDMATRVGATEVVMTTMEEEIMEVEITMILEIITSNLLTTVQ

Approximately 48 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.