ICOS 蛋白, Human (HEK293, Fc)

ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (HEK293, Fc) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag.

ICOS 蛋白显着增强 T 细胞对外源抗原的基本反应，包括细胞增殖、淋巴因子分泌、细胞间相互作用分子上调以及有效促进 B 细胞抗体分泌等关键活性。事实证明，它对于 T 细胞和 B 细胞之间的有效相互作用至关重要，对于 T 细胞依赖性抗原的正常抗体反应至关重要。尽管不影响白细胞介素 2 的产生，ICOS 蛋白仍可诱导白细胞介素 10 的合成并防止预激活 T 细胞的凋亡。此外，ICOS 在 CD40 介导的免疫球蛋白同种型类别转换中发挥着关键作用，证明了其在协调免疫反应中的多方面作用。该蛋白质形成通过二硫键连接的同二聚体，进一步增强了其功能特性。

Human

HEK293

C-hFc

Q9Y6W8-1 (E21-F141)

29851  [NCBI]

EINGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHSHANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKF

Approximately 47 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.