ICOS - inducible T cell costimulator Gene

中文名称：诱导型 T 细胞共刺激物

种属: Homo sapiens

同用名: AILIM; CD278; CVID1

基因 ID: 29851 | 基因类型: protein coding

关于 ICOS

Cytogenetic location: 2q33.2 Genomic coordinates (GRCh38): 2:203,936,763-203,961,577 (from NCBI)

This gene has 2 transcripts (splice variants), 115 orthologues and is associated with 3 phenotypes. Biased expression in lymph node (RPKM 7.8), bone marrow (RPKM 6.5) and 9 other tissues.

功能概要

该基因编码的蛋白质属于 CD28 和 CTLA-4 细胞表面受体家族。它形成同源二聚体，在细胞间信号传导、免疫反应和细胞增殖调节中发挥重要作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

ICOS 基因产物(1)

mRNA	Protein	Name
NM_012092.4	NP_036224.1	inducible T-cell costimulator precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11956294	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

inducible T-cell costimulator

activation-inducible lymphocyte immunomediatory molecule

ICOS 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ICOS	Q9Y6W8	ICOSLG	Homo sapiens	O75144	ELISA	11956294
种属内	ICOS	Q9Y6W8	ICOSLG	Homo sapiens	O75144	SPR	11956294
种属内	ICOS	Q9Y6W8	ICOSLG	Homo sapiens	O75144	Far-WB	16951355
种属内	ICOS	Q9Y6W8	TBK1	Homo sapiens	Q9UHD2	Anti Bait CoIP	27135603
种属内	ICOS	Q9Y6W8	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	18641334
种属内	ICOS	Q9Y6W8	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	27135603

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ICOS 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72618	ICOS Protein, Human (HEK293, Fc)	Q9Y6W8-1 (E21-F141)	≥95%
HY-P76396	ICOS Protein, Human (HEK293, His-Fc)	Q9Y6W8-1 (E21-F141)	≥95%
HY-P78546	ICOS Protein, Human (C136S, C137S, HEK293, His)	Q9Y6W8-1 (E21-F141, C136S, C137S)	≥95%

关联疾病

疾病名称

别名

Immunodeficiency, Common Variable, 1

CVID1	Antibody Deficiency Due To Icos Defect
Icos Deficiency	Common Variable Immunodeficiency 1
Immunodeficiency, Variable, Common, Type 1

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Immunodeficiency, Common Variable, 2

CVID2	Antibody Deficiency Due To Taci Defect
Hypogammaglobulinemia Due To Taci Deficiency	Common Variable Immunodeficiency 2
Immunodeficiency, Variable, Common, Type 2

Dermatitis, Atopic, 5

ATOD5	Atopic Dermatitis 5
Dermatitis, Atopic, Susceptibility To, 5	Dermatitis, Atopic 5

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99420	Acazicolcept	Antagonist	99.27%	Phase 2
HY-P99474	Bertilimumab	Inhibitor	/	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-162810	ICOS-IN-1		/	否
HY-RS06520	ICOS Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W011267	(Z)-Methyl icos-11-enoate		/	否
HY-166209	Ethyl 8(Z)-eicosenoate		/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P99679	Izuralimab	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ICOS	RGD	RGD:620123
Canis familiaris	ICOS	VGNC	VGNC:41861
Mus musculus	ICOS	MGD	MGI:1858745
Macaca mulatta	ICOS	VGNC	VGNC:73555
Bos taurus	ICOS	VGNC	VGNC:30030
Felis catus	ICOS	VGNC	VGNC:80240
Macaca fascicularis	ICOS	NCBI	NCBI:102116512
Others	ICOS	NCBI

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