2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens
  4. Stimulatory Immune Checkpoint Molecules T Cell CD Proteins
  5. ICOS/CD278 ICOS/CD278
  6. ICOS 蛋白, Human (C136S, C137S, HEK293, His)

ICOS 蛋白, Human (C136S, C137S, HEK293, His)

目录号: HY-P78546
产品使用指南

ICOS蛋白增强T细胞对外来抗原的反应，促进增殖、淋巴因子分泌、细胞间相互作用分子的上调，并帮助B细胞分泌抗体。ICOS 蛋白, Human (C136S, C137S, HEK293, His) 是重组的 ICOS 蛋白，由 HEK293 表达，带有 C-His 标签。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (C136S, C137S, HEK293, His) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-His labeled tag.
研究背景

ICOS 蛋白显着增强 T 细胞对外源抗原的基本反应，包括细胞增殖、淋巴因子分泌、细胞间相互作用分子上调以及有效促进 B 细胞抗体分泌等关键活性。事实证明，它对于 T 细胞和 B 细胞之间的有效相互作用至关重要，对于 T 细胞依赖性抗原的正常抗体反应至关重要。尽管不影响白细胞介素 2 的产生，ICOS 蛋白仍可诱导白细胞介素 10 的合成并防止预激活 T 细胞的凋亡。此外，ICOS 在 CD40 介导的免疫球蛋白同种型类别转换中发挥着关键作用，证明了其在协调免疫反应中的多方面作用。该蛋白质形成通过二硫键连接的同二聚体，进一步增强了其功能特性。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

Q9Y6W8-1 (E21-F141, C136S, C137S)
基因 ID
蛋白结构
N-term
ICOS (E21-F141, C136S, C137S)
Accession # Q9Y6W8-1
His
C-term
同用名
AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850
分子量

35-40 kDa
纯度

Greater than 95% as determined by Tris-Bis PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
ICOS Protein, Human (C136S, C137S, HEK293, His)
目录号：
HY-P78546
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z