IL-36RN 蛋白, Mouse

IL-36RN protein exhibits cytokine activity, interleukin 1 receptor antagonist activity, and interleukin 1 receptor binding activity. It negatively regulates IL-6 production and is predicted to be localized in the cytoplasm and extracellular regions. IL-36RN Protein, Mouse is the recombinant mouse-derived IL-36RN protein, expressed by E. coli , with tag free. The total length of IL-36RN Protein, Mouse is 154 a.a., with molecular weight of ~17 kDa.

IL-36RN 蛋白预计具有多种重要的功能属性，包括细胞因子活性、白细胞介素 1 受体拮抗剂活性和白细胞介素 1 受体结合活性。它在 IL-6 产生的上游或负调控中发挥作用。预计该蛋白质位于细胞质和细胞外区域，表明它可能参与多种细胞过程。此外，IL-36RN 预计在细胞外空间具有活性。在人类中，该基因与脓疱型银屑病 14 相关，表明其与皮肤病理学的相关性。值得注意的是，IL-36RN 与人白细胞介素 36 受体拮抗剂 (IL36RN) 具有同源性。表达分析揭示了成人胃 (RPKM 9.0) 和肺 (RPKM 1.0) 中的偏向表达，强调了其在这些组织中的潜在意义。

Measured by its ability to inhibit IL-36 beta induced IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The ED₅₀ for this effect is 0.8070 μg/mL, corresponding to a specific activity is 1239.1574 U/mg, in the presence of 15 ng/mL of Recombinant Mouse IL-36 beta.

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  Measured by its ability to inhibit IL-36 beta induced IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The ED₅₀for this effect is 0.8070 μg/mL, corresponding to a specific activity is 1239.1574 U/mg, in the presence of 15ng/mL of Recombinant Mouse IL-36 beta.

Mouse

E. coli

Tag Free

NP_062324.2 (V3-D156)

54450  [NCBI]

VLSGALCFRMKDSALKVLYLHNNQLLAGGLHAEKVIKGEEISVVPNRALDASLSPVILGVQGGSQCLSCGTEKGPILKLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTSPEADQPVRLTQIPEDPAWDAPITDFYFQQCD

Approximately 19-24 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.