Interferon tau-1/IFNT1 蛋白, Bovine (P.pastoris, His)

Interferon tau-1 (IFNT1) serves as an important paracrine hormone that initiates maternal recognition of pregnancy. After interacting with endometrial receptors, possibly type I interferon receptors, IFNT1 blocks estrogen receptor expression and prevents estrogen-induced upregulation of oxytocin receptor expression. Interferon tau-1/IFNT1 Protein, Bovine (P.pastoris, His) is the recombinant bovine-derived Interferon tau-1/IFNT1 protein, expressed by P. pastoris , with N-His labeled tag.

干扰素 tau-1 (IFNT1) 是一种旁分泌激素，对于启动母亲对妊娠的识别至关重要。在与子宫内膜受体（可能是 I 型干扰素受体）相互作用后，IFNT1 在阻断雌激素受体表达方面发挥着至关重要的作用，有效阻止雌激素诱导的子宫内膜催产素受体表达上调。这种机制导致子宫内膜脉冲性释放黄体溶解激素前列腺素 F2-α 受到抑制，从而防止黄体消退（黄体溶解）并促进卵巢周期的维持。此外，IFNT1可能通过直接影响前列腺素合成，维持卵巢孕酮分泌，刺激子宫内膜分泌孕体生长所需的营养物质。值得注意的是，IFNT1 表现出卓越的抗病毒和抗增殖功效，同时具有低细胞毒性、高抗黄体溶解活性和免疫调节特性。与其他干扰素相比，它的一个显着特征是缺乏病毒诱导性。

Bovine

P. pastoris

N-His

P15696 (C24-L195)

317698  [NCBI]

CYLSEDHMLGARENLRLLARMNRLSPHPCLQDRKDFGLPQEMVEGNQLQKDQAISVLHEMLQQCFNLFYTEHSSAAWNTTLLEQLCTGLQQQLEDLDACLGPVMGEKDSDMGRMGPILTVKKYFQGIHVYLKEKEYSDCAWEIIRVEMMRALSSSTTLQKRLRKMGGDLNSL

Approximately 21.8 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against solution in 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.