KIRREL2/NEPH3 蛋白, Human (HEK293, Fc)

KIRREL2/NEPH3 proteins may regulate basal insulin secretion and participate in self-association as homodimers. Functionally, it interacts with NPHS2/podocin, NPHS1 and FYN, contributing to key molecular interactions in cellular processes. KIRREL2/NEPH3 Protein, Human (HEK293, Fc) is the recombinant human-derived KIRREL2/NEPH3 protein, expressed by HEK293 , with C-hFc labeled tag.

KIRREL2/NEPH3 蛋白可能参与调节基础胰岛素分泌，表明其参与了胰岛素释放的复杂过程。在结构上，它形成同二聚体，表明它具有参与自缔合的能力。在功能上，KIRREL2/NEPH3 与 NPHS2/podocin、NPHS1 和 FYN 等关键蛋白相互作用，突显其参与对细胞过程至关重要的分子相互作用。与 NPHS2/podocin 的相互作用通过 C 末端发生，而与 NPHS1 的相互作用则涉及 Ig 样结构域，这表明了不同的结合机制。此外，与 FYN 的关联为其在细胞信号通路中的潜在作用增加了一层复杂性。KIRREL2/NEPH3 的多方面相互作用和潜在的调节作用强调了其在胰岛素分泌以外的细胞功能中的重要性，需要进一步研究以揭示其对各种生物过程的精确贡献。

Human

HEK293

C-hFc

Q6UWL6-1 (G21-R503)

84063  [NCBI]

GPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRR

Approximately 85-95 kDa.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.