2. 重组蛋白
  3. CD Antigens Receptor Proteins Biotinylated Proteins
  4. NK Cell CD Proteins
  5. CD336/NCR2
  6. NKp44/NCR2 蛋白, Human (Biotinylated, 169a.a, HEK293, His)

NKp44/NCR2 蛋白, Human (Biotinylated, 169a.a, HEK293, His)

目录号: HY-P74685
产品使用指南

NKp44/NCR2 蛋白是自然杀伤 (NK) 细胞上的一种细胞毒性激活受体，可以提高肿瘤细胞的裂解效率。NKp44/NCR2 与 TYROBP/DAP12 相互作用，TYROBP/DAP12 是一种重要的信号转导接头，对于转导激活 NK 细胞对抗靶细胞的信号至关重要。NKp44/NCR2 蛋白, Human (Biotinylated, 169a.a, HEK293, His) 是重组的 NKp44/NCR2 蛋白，由 HEK293 表达，带有 C-His 标签。NKp44/NCR2 蛋白, Human (Biotinylated, 169a.a, HEK293, His) 全长 169 个氨基酸，分子量约为 ~20 kDa。

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描述

The NKp44/NCR2 protein is a cytotoxicity-activating receptor on natural killer (NK) cells that may increase their tumor cell lysis efficiency. NKp44/NCR2 interacts with TYROBP/DAP12, an important signal transduction adapter, and is critical for transducing signals that activate NK cells against target cells. NKp44/NCR2 Protein, Human (Biotinylated, 169a.a, HEK293, His) is the recombinant human-derived NKp44/NCR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of NKp44/NCR2 Protein, Human (Biotinylated, 169a.a, HEK293, His) is 169 a.a., with molecular weight of ~20 kDa.
研究背景

NKp44/NCR2 蛋白作为细胞毒性激活受体发挥作用，可能增强激活的自然杀伤 (NK) 细胞介导肿瘤细胞裂解的效率。该受体与 TYROBP/DAP12 相互作用，TYROBP/DAP12 是一种重要的信号转接蛋白，对于转导导致 NK 细胞激活和针对靶细胞的细胞毒性的信号至关重要。此外，NKp44/NCR2 蛋白与 KMT2E 亚型 NKp44L 相互作用，进一步促进参与 NK 细胞反应调节的复杂分子相互作用。NKp44/NCR2 与这些信号传导伙伴的协同作用强调了其在活化 NK 细胞的免疫监视和抗肿瘤活性中的重要性。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

O95944 (Q22-P190)
基因 ID
蛋白结构
N-term
NKp44 (Q22-P190)
Accession # O95944
His
C-term
同用名
Natural cytotoxicity triggering receptor 2; NKp44; CD336; NCR2; LY95
分子量

Approximately 20 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

NKp44/NCR2 Protein, Human (Biotinylated, 169a.a, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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