NCR2 - natural cytotoxicity triggering receptor 2 Gene

中文名称：天然细胞毒性触发受体 2

种属: Homo sapiens

同用名: LY95; CD336; NKP44; NK-p44; dJ149M18.1

基因 ID: 9436 | 基因类型: protein coding

关于 NCR2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,335,608-41,350,889 (from NCBI)

This gene has 3 transcripts (splice variants), 74 orthologues and 2 paralogues. Low expression observed in reference dataset.

功能概要

预测启用信号受体活动。预计参与细胞防御反应和信号转导。预测位于质膜中。预计是质膜的组成部分。预计在细胞表面有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable signaling receptor activity. Predicted to be involved in cellular defense response and signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

NCR2 基因产物(3)

mRNA	Protein	Name
NM_001199509.2	NP_001186438.1	natural cytotoxicity triggering receptor 2 isoform 2 precursor
NM_001199510.2	NP_001186439.1	natural cytotoxicity triggering receptor 2 isoform 3 precursor
NM_004828.4	NP_004819.2	natural cytotoxicity triggering receptor 2 isoform 1 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10049942	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCR2 蛋白结构

V-set

0
100
200
276 a.a.

蛋白主名

其他名称

natural cytotoxicity triggering receptor 2

NK cell activating receptor (NKp44)

NCR2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NCR2	O95944	KMT2E	Homo sapiens	Q8IZD2-8	LexA B52 Complement	23958951
种属内	NCR2	O95944	KMT2E	Homo sapiens	Q8IZD2-8	Anti Bait CoIP	23958951
种属内	NCR2	O95944	KMT2E	Homo sapiens	Q8IZD2-8	Far-WB	23958951
种属内	NCR2	O95944	TYROBP	Homo sapiens	O43914	Anti Bait CoIP	14707061
种属内	NCR2	O95944	TYROBP	Homo sapiens	O43914	Anti Bait CoIP	10049942

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NCR2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72502	NKp44/NCR2 Protein, Human (HEK293, His)	O95944/NP_004819.2 (Q22-P190)	≥95%
HY-P74685	NKp44/NCR2 Protein, Human (Biotinylated, 169a.a, HEK293, His)	O95944 (Q22-P190)	≥95%

关联疾病

疾病名称

别名

Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest

Nk Cell Deficiency

Dermatitis, Atopic, 5

ATOD5	Atopic Dermatitis 5
Dermatitis, Atopic, Susceptibility To, 5	Dermatitis, Atopic 5

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09099	NCR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NCR2	RGD	RGD:1311406
Felis catus	NCR2	VGNC	VGNC:102474
Macaca mulatta	NCR2	VGNC	VGNC:75066
Others	NCR2	NCBI

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