NKp44/NCR2 蛋白, Human (HEK293, His)

The NKp44/NCR2 protein is a cytotoxicity-activating receptor on natural killer (NK) cells that may increase their tumor cell lysis efficiency. NKp44/NCR2 interacts with TYROBP/DAP12, an important signal transduction adapter, and is critical for transducing signals that activate NK cells against target cells. NKp44/NCR2 Protein, Human (HEK293, His) is the recombinant human-derived NKp44/NCR2 protein, expressed by HEK293 , with C-6*His labeled tag.

NKp44/NCR2 蛋白作为细胞毒性激活受体发挥作用，可能增强激活的自然杀伤 (NK) 细胞介导肿瘤细胞裂解的效率。该受体与 TYROBP/DAP12 相互作用，TYROBP/DAP12 是一种重要的信号转接蛋白，对于转导导致 NK 细胞激活和针对靶细胞的细胞毒性的信号至关重要。此外，NKp44/NCR2 蛋白与 KMT2E 亚型 NKp44L 相互作用，进一步促进参与 NK 细胞反应调节的复杂分子相互作用。NKp44/NCR2 与这些信号传导伙伴的协同作用强调了其在活化 NK 细胞的免疫监视和抗肿瘤活性中的重要性。

Human

HEK293

C-6*His

O95944/NP_004819.2 (Q22-P190)

9436  [NCBI]

QSKAQVLQSVAGQTLTVRCQYPPTGSLYEKKGWCKEASALVCIRLVTSSKPRTMAWTSRFTIWDDPDAGFFTVTMTDLREEDSGHYWCRIYRPSDNSVSKSVRFYLVVSPASASTQTSWTPRDLVSSQTQTQSCVPPTAGARQAPESPSTIPVPSQPQNSTLRPGPAAP

Approximately 30-40 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 ,8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.