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  3. REG-3 alpha/REG3A 蛋白, Rat (HEK293, His)

REG-3 alpha/REG3A 蛋白, Rat (HEK293, His)

目录号: HY-P76570
产品使用指南

REG-3 α/REG3A 蛋白是一种杀菌 C 型凝集素,缺乏 EPN 基序,可作为响应 IL17A 和肠道微生物组等刺激的激素。它由多种细胞类型分泌,并激活受体 EXTL3,启动细胞特异性信号传导途径。REG-3 alpha/REG3A 蛋白, Rat (HEK293, His) 是重组的 REG-3 alpha/REG3A 蛋白,由 HEK293 表达,带有 C-His 标签。REG-3 alpha/REG3A 蛋白, Rat (HEK293, His) 全长 149 个氨基酸,分子量约为 ~17 kDa。

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描述

REG-3 α/REG3A protein is a bactericidal C-type lectin lacking an EPN motif that acts as a hormone in response to stimuli such as IL17A and the intestinal microbiome. It is secreted by various cell types and activates the receptor EXTL3, initiating cell-specific signaling pathways. REG-3 alpha/REG3A Protein, Rat (HEK293, His) is the recombinant rat-derived REG-3 alpha/REG3A protein, expressed by HEK293 , with C-His labeled tag. The total length of REG-3 alpha/REG3A Protein, Rat (HEK293, His) is 149 a.a., with molecular weight of ~17 kDa.

研究背景

REG-3 α/REG3A 蛋白是一种杀菌性 C 型凝集素,缺乏 EPN 基序,这可能解释了它无法结合肽聚糖的原因。它作为一种激素来响应各种刺激,包括 IL17A 和肠道微生物组等抗炎信号。REG-3 α/REG3A 蛋白由不同细胞类型分泌,并激活其受体 EXTL3,启动细胞特异性信号通路。在角质形成细胞中,它由 IL17A 诱导,在皮肤损伤后调节角质形成细胞增殖和分化中发挥作用。它还通过抑制 IL6 和 TNF 等炎症细胞因子来抑制皮肤炎症。在胰腺中,REG-3 α/REG3A 蛋白能够透化 β 细胞膜并刺激其增殖。

种属

Rat

表达系统

HEK293

标签

C-His

蛋白编号

P35231 (E26-Q174)

基因 ID
蛋白结构
N-term
REG3A (E26-Q174)
Accession # P35231
His
C-term
同用名
Regenerating islet-derived protein 3-alpha; REG-3-alpha; Lithostathine 3; PAP2
分子量

Approximately 17 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

REG-3 alpha/REG3A Protein, Rat (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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REG-3 alpha/REG3A Protein, Rat (HEK293, His)
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