SF20/MYDGF 蛋白, Mouse

SF20/MYDGF protein promotes cardiac myocyte survival and adaptive angiogenesis after myocardial infarction (MI). It stimulates endothelial cell proliferation via MAPK1/3, STAT3, and CCND1 signaling, and inhibits cardiac myocyte apoptosis through PI3K/AKT signaling. Given its ability to enhance cardiac function and angiogenesis, SF20/MYDGF protein could be a valuable therapeutic target for improving outcomes in MI patients. SF20/MYDGF Protein, Mouse is the recombinant mouse-derived SF20/MYDGF, expressed by E. coli , with tag Free labeled tag. ,

SF20/MYDGF 蛋白是一种骨髓来源的单核细胞和旁分泌作用蛋白，在促进心肌细胞存活和适应性血管生成以实现心肌梗死 (MI) 后的心脏保护和修复方面发挥着至关重要的作用。它通过涉及 MAPK1/3、STAT3 和 CCND1 的信号通路刺激内皮细胞增殖来发挥作用。此外，SF20/MYDGF 蛋白通过依赖 PI3K/AKT 的信号通路抑制心肌细胞凋亡。这种蛋白质增强心脏功能和促进血管生成的能力使其成为治疗心肌梗死和改善心脏结局的潜在治疗靶点。

Measured by its binding ability in a functional ELISA. When Recombinant Mouse SF20 is used at 2 μg/mL can bind Recombinant Human P4HB. The ED₅₀ for this effect is 0.681 μg/mL.

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  Measured by its binding ability in a functional ELISA. When Recombinant Mouse SF20 is used at 2 μg/mL can bind Recombinant Human P4HB. The ED₅₀ for this effect is 0.681 μg/mL.

Mouse

E. coli

Tag Free

Q9CPT4 (V25-L166)

28106  [NCBI]

VSEPTTVPFDVRPGGVVHSFSQDVGPGNKFTCTFTYASQGGTNEQWQMSLGTSEDSQHFTCTIWRPQGKSYLYFTQFKAELRGAEIEYAMAYSKAAFERESDVPLKSEEFEVTKTAVSHRPGAFKAELSKLVIVAKAARSEL

Approximately 16 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filter solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.