SYNGAP1 蛋白, Human (His)

SYNGAP1 protein is a major postsynaptic density component that plays a critical regulatory role in the Ras-cAMP pathway, affecting synaptic function and plasticity. At excitatory synapses, it is part of the NMDAR signaling complex and may influence NMDAR-dependent control of AMPAR potentiation, trafficking, and synaptic plasticity. SYNGAP1 Protein, Human (His) is the recombinant human-derived SYNGAP1 protein, expressed by E. coli , with N-His labeled tag. The total length of SYNGAP1 Protein, Human (His) is 183 a.a., with molecular weight of ~25.5 kDa.

SYNGAP1 蛋白作为突触后密度 (PSD) 的主要成分占据中心地位，在突触后信号传导中发挥着至关重要的作用。SYNGAP1 作为 Ras-cAMP 通路的抑制性调节因子，是突触功能和可塑性不可或缺的一部分。在兴奋性突触内，它作为 NMDAR 信号复合体的成员，可能影响 NMDAR 依赖性的 AMPAR 增强控制、AMPAR 膜运输和整体突触可塑性。此外，SYNGAP1 调节 AMPAR 介导的微型兴奋性突触后电流，并对 Ras 和 Rap 表现出双重 GTP 酶激活特异性。与 KLHL17、CAMK2A、CAMK2B 和 MPDZ 的相互作用凸显了其在突触信号传导通路中的复杂网络。值得注意的是，它可能与某些形式的脑损伤有关，导致学习和记忆的长期缺陷，强调了它在神经功能中的关键作用。

Human

E. coli

N-His

Q96PV0 (1161M-1343H)

8831  [NCBI]

MPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAPPAPPPPPRLQITENGEFRNTADH

Approximately 25.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.