TWSG1 蛋白, Human (HEK293, His)

The TWSG1 protein plays a dual role in BMP signaling, acting as both an antagonist and an agonist. It forms a ternary complex with CHRD and BMP, blocking BMP receptor binding, thereby antagonizing BMP signaling. TWSG1 Protein, Human (HEK293, His) is the recombinant human-derived TWSG1 protein, expressed by HEK293 , with C-6*His labeled tag.

TWSG1 蛋白是背腹轴形成的关键参与者，在 BMP 信号传导的调节中显示出双重作用。它似乎既充当拮抗剂又充当激动剂，影响 BMP 信号动力学。TWSG1 通过与 CHRD 和 BMP 形成三元复合物来拮抗 BMP 信号传导，从而阻碍 BMP 与其受体结合。同时，TWSG1 表现出 pro-BMP 活性，部分是通过 CHRD 的裂解和降解促进的，从三元复合物中释放 BMP。这种双重功能表明 TWSG1 可能复杂地调节 BMP 介导的过程，特别是在软骨发育和软骨细胞分化中。此外，它在胸腺细胞发育中的潜在作用意味着对细胞分化过程具有更广泛的影响。与关键伙伴（包括 CHRD、BMP4 和 BMP7）的相互作用进一步强调了 TWSG1 在 BMP 信号通路调节中的复杂参与。阐明控制 TWSG1 双重作用的具体机制可以为其在发育和分化过程中的多方面作用提供有价值的见解。

Human

HEK293

C-6*His

Q9GZX9-1 (C26-F223)

57045  [NCBI]

CNKALCASDVSKCLIQELCQCRPGEGNCSCCKECMLCLGALWDECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSLFRALTEGDTQLNWNIVSFPVAEELSHHENLVSFLETVNQPHHQNVSVPSNNVHAPYSSDKEHMCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSKTVKCMNCMF

Approximately 35.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.