2. 点击化学
  3. 炔烃
  4. RM-581

RM-581 是一种氨基类固醇衍生物，对不同类型的癌症(包括高致死性胰腺癌)具有强效的抗癌活性。RM-581 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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RM-581 Chemical Structure

RM-581 Chemical Structure

CAS No. : 2086809-59-6

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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RM-581 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RM-581, an aminosteroid derivative, has potent anticancer activity in different types of cancer, including high fatality pancreatic cancer[1]. RM-581 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
LAPC4 IC50
0.6 μM
Compound: RM-581
Antiproliferative activity against human LAPC4 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human LAPC4 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
LNCaP IC50
1.2 μM
Compound: RM-581
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
MCF7 IC50
2.6 μM
Compound: RM-581
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
OVCAR-3 IC50
5 μM
Compound: RM-581
Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
PANC-1 IC50
3.9 μM
Compound: RM-581
Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
PC-3 IC50
1.6 μM
Compound: RM-581
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
T47D IC50
0.5 μM
Compound: RM-581
Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
分子量

646.82

Formula

C40H46N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RM-581 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RM-5812086809-59-6RM581RM 581OthersAminosteroidanticancerpancreaticInhibitorinhibitorinhibit

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