2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. RP 67580

RP 67580 是 P 物质（SP）的非肽拮抗剂，竞争性抑制大鼠脑膜中 [3H]SP 与神经激肽受体 1（NK1 受体）的结合，Ki 值为 4.16 nM。 RP 67580 还是 NK1 受体的特异性拮抗剂,可用于疼痛和神经源性炎症的研究。

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RP 67580 Chemical Structure

RP 67580 Chemical Structure

CAS No. : 135911-02-3

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规格 价格 是否有货 数量
5 mg ￥3903
3 - 4 周
10 mg 现货 3 - 4 周
50 mg   询价  
100 mg   询价  

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RP 67580 相关抗体

Top Publications Citing Use of Products

查看 Neurokinin Receptor 亚型特异性产品:

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NK1 NK2 NK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a Ki value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
IM-9 IC50
30 nM
Compound: 2
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
[PMID: 8576917]
体内研究
(In Vivo)

RP 67580（0.03-1 mg/kg；静脉注射；单剂量）显著抑制神经源性炎症。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male albino Sprague-Dawley rats
Dosage: 0.03, 0.1, 0.3, 1 mg/kg
Administration: i.v.; single dose
Result: Potently and dose-dependently inhibited the strong plasma extravasation caused by electrical stimulation of the saphenous nerve for 15 minutes with an ED50 value of 0.15 mg/kg.
分子量

438.56

Formula

C29H30N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RP 67580 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RP 67580135911-02-3RP67580RP-67580Neurokinin ReceptorNK receptorTachykinin receptorNK1 receptorsubstance Pneurogenic inflammationInhibitorinhibitorinhibit

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产品名称：
RP 67580
目录号：
HY-108483
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