Serum thymic factor  (Synonyms: Thymulin; Thymic factor)

Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases^[1][2][3][4].

858.85

C₃₃H₅₄N₁₂O₁₅

63958-90-7

{Pyr}-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn

{Pyr}-AKSQGGSN

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• [1]. Dardenne M,et al. Role of thymulin or its analogue as a new analgesic molecule. Ann N Y Acad Sci. 2006 Nov;1088:153-63.  [Content Brief]

  [2]. Kohda Y, et al. Protective effect of serum thymic factor, FTS, on cephaloridine-induced nephrotoxicity in rats. Biol Pharm Bull. 2005 Nov;28(11):2087-91.  [Content Brief]

  [3]. Mizutani M, et al. In vivo administration of serum thymic factor (FTS) prevents EMC-D virus-induced diabetes and myocarditis in BALB/cAJcl mice. Arch Virol. 1996;141(1):73-83.  [Content Brief]

  [4]. Pardo J, et al. Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin[J]. Physiological Mini Reviews (PMR), 2012, 6.