2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis HCV SARS-CoV
  4. Setrobuvir

Setrobuvir (ANA598) 是一种口服活性的非核苷 HCV NS5B 聚合酶抑制剂。Setrobuvir 抑制 RNA 的从头合成 (RNA synthesis) 和引物延伸，IC50在 4~5 nM 之间。Setrobuvir 还显示出与 SARS-CoV-2 RdRp 的优异结合亲和力，并诱导 RdRp 抑制。

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Setrobuvir Chemical Structure

Setrobuvir Chemical Structure

CAS No. : 1071517-39-9

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规格 价格 是否有货 数量
1 mg ￥2805
1 - 2 周
5 mg   询价  
10 mg   询价  

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Customer Review

Setrobuvir 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC50s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition[1][2].

体外研究
(In Vitro)

Setrobuvir (ANA598) is a non-nucleoside inhibitor that binds to the palm pocket of the HCV polymerase and has an EC50 against HCV genotype 1b/Con1-containing subgenomic replicons in the nanomolar range. Setrobuvir appears to inhibit both de novoinitiated RNA synthesis and primer extension, and its activity is unchanged by the presence of mutations that modify the activity of thumb-binding non-nucleoside inhibitors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Setrobuvir 相关抗体:
Clinical Trial
分子量

560.62

Formula

C25H25FN4O6S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Setrobuvir 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Setrobuvir1071517-39-9ANA598ANA 598ANA-598DNA/RNA SynthesisHCVSARS-CoVHepatitis C virusSARS coronaviruspolymeraseRNAsynthesisprimerextensionmutationInhibitorinhibitorinhibit

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目录号：
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