2. Immunology/Inflammation Apoptosis
  3. NTPDase Pyroptosis
  4. Sodium metatungstate hydrate

Sodium metatungstate hydrate  (Synonyms: Sodium polyoxotungstate hydrate; POM-1 hydrate)

目录号: HY-103259A
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Sodium metatungstate (Sodium polyoxotungstate; POM-1) hydrate 是 NTPDase 抑制剂，NTPDase 1 (CD39)、NTPDase 3 和 NTPDase 2 的 Ki 的值分别为 2.58 μM、3.26 μM 和 28.8 μM。Sodium metatungstate hydrate 具有抗炎和抗癌作用。Sodium metatungstate hydrate 抑制 ATP 分解，但也阻断中枢突触传递。

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Sodium metatungstate hydrate Chemical Structure

Sodium metatungstate hydrate Chemical Structure

CAS No. : 314075-43-9

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Sodium metatungstate hydrate 的其他形式现货产品:

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Sodium metatungstate hydrate 相关抗体

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  • 生物活性

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生物活性

Sodium metatungstate (Sodium polyoxotungstate; POM-1) hydrate is a NTPDase inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively[1]. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission[1][2][3][4].

IC50 & Target

Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2)[1].
体外研究
(In Vitro)

Sodium metatungstate hydrate (100 μM, 15 min) 在巨噬细胞中抑制 ATP 诱导的阴离子染料摄取和大通道[2]。
Sodium metatungstate hydrate (100 μM, 8 h) 抑制 ATP 诱导的 P2X7 相关巨噬细胞焦亡[2]。
Sodium metatungstate hydrate (100 μM, 8-24 h) 对巨噬细胞有很强的抗炎作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium metatungstate hydrate 相关抗体:
体内研究
(In Vivo)

Sodium metatungstate hydrate (5 mg/kg，腹腔注射，单次剂量) 在 CD39 基因敲除小鼠的腹膜和全身血流中显示出不同的细胞因子/趋化因子反应[3]。
Sodium metatungstate hydrate (5 mg/kg，腹腔注射，一天一次，从第 0 天至第 4 天、第 7 天至第 11 天、第14 天至第 18 天) 联合抗 CD73 抗体和 AZD4635(HY-101980) 可降低多发性骨髓瘤 (MM) 小鼠的肿瘤负荷[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Multiple myeloma (MM) mice developed by 3 weeks of injection of 5t33MM cells[4]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Had significantly lower spleen weights, fewer tumor cells in the spleen as well as significantly lower monoclonal immunoglobulin component level in circulation.
分子量

2968 (anhydrous basis)

Formula

3Na2WO4.9WO3.xH2O
CAS 号
中文名称

聚钨酸钠水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sodium metatungstate hydrate 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Sodium metatungstate314075-43-9Sodium polyoxotungstatePOM-1聚钨酸钠水合物POM1POM 1NTPDasePyroptosismacrophageCD39 knockout miceMultiple myeloma miceInhibitorinhibitorinhibit

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