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SORT-PGRN interaction inhibitor 2 

目录号: HY-153687
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SORT-PGRN interaction inhibitor 2 是一种 SORT-PGRN 抑制剂，能在哺乳动物细胞内降低 SORT1 蛋白表达，增加细胞外 PGRN 分泌的化合物，可用于神经系统疾病相关研究。

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SORT-PGRN interaction inhibitor 2 Chemical Structure

SORT-PGRN interaction inhibitor 2 Chemical Structure

CAS No. : 1008233-79-1

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SORT-PGRN interaction inhibitor 2 相关抗体

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生物活性

SORT-PGRN interaction inhibitor 2 is a SORT-PGRN inhibitor that can decreases SORT1 protein expression and increases extracellular PGRN secretion in mammalian cell lines. SORT-PGRN interaction inhibitor 2 can be used for neurological disease research[1].

体外研究
(In Vitro)

SORT-PGRN interaction inhibitor 2 (Compound MPEP) ( 0-20 μΜ；24 小时) 在哺乳动物细胞系中降低 SORT1 的表达，增加细胞外 PGRN 分泌[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SORT-PGRN interaction inhibitor 2 相关抗体:

Western Blot Analysis[1]

Cell Line: M17 cells, lymphoblastoid cell lines (LCLs) and iPSCs neurons, LCLs from two FTD-GRN families( UBC17 and UBC15)
Concentration: 0, 5, 10, 20 μM
Incubation Time: 24 h
Result: Preferentially increased extracellular PGRN levels by suppressing or reducing intracellular SORT1 levels without affecting sortilin-related family members SORLA and SORCS1.
Made exPGRN levels in the heterozygous mutation carrier (GRN+/2-LCL) restored to a level comparable with the homozygous non-carrier (GRN+/+-LCL) in p.R418X mutation in family UBC17.
Made exPGRN levels in the UBC15 family restored to 80% of that of noncarrier GRN+/+-LCL levels.
分子量

289.46

Formula

C19H31NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SORT-PGRN interaction inhibitor 2 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

SORT-PGRN interaction inhibitor 21008233-79-1OthersM17 cellslymphoblastoid cell lines (LCLs)cellular models of FTD-GRNsortilin– progranulin axisInhibitorinhibitorinhibit

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