2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. SPD-502 sodium

SPD-502 sodium  (Synonyms: NS-1209 sodium)

目录号: HY-15076
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摩尔计算器

SPD-502 sodium 是一种谷氨酸拮抗剂，具有潜在的神经保护特性，尤其是在脑缺血中。它选择性地靶向 AMPA 受体，表现出高亲和力 (IC50 = 0.043 μM) 和对大鼠皮质膜和培养的小鼠皮质神经元中 AMPA 诱导效应的竞争性抑制。体内，SPD-5??02 在静脉注射后有效阻断海马中 AMPA 诱发的尖峰活动，显著提高小鼠的癫痫发作阈值，并显示出对沙鼠海马神经元缺血诱导损伤的强大保护作用。这些发现表明 SPD-502 可能有望用于治疗与谷氨酸兴奋毒性相关的神经退行性疾病。

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SPD-502 sodium Chemical Structure

SPD-502 sodium Chemical Structure

CAS No. : 205645-02-9

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Other Forms of SPD-502 sodium:

SPD-502 sodium 相关抗体

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  • 生物活性

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生物活性

SPD-502 sodium is a novel glutamate antagonist with potential neuroprotective properties, particularly in brain ischemia. It selectively targets the AMPA receptor, showing high affinity (IC50 = 0.043 μM) and competitive inhibition of AMPA-induced effects in rat cortical membranes and cultured mouse cortical neurons. In vivo, SPD-502 sodium effectively blocks AMPA-evoked spike activity in the hippocampus after intravenous administration, significantly increasing the seizure threshold in mice and demonstrating robust protection against ischemia-induced damage to hippocampal neurons in gerbils. These findings suggest SPD-502 sodium may be promising for treating neurodegenerative conditions associated with glutamate excitotoxicity[1].

分子量

538.55

Formula

C24H27N4NaO7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SPD-502 sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

SPD-502205645-02-9NS-1209SPD502SPD 502NS1209NS 1209iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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