2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. SR-4133

SR-4133 是一种 CK1ε 高效选择性抑制剂，其IC50 为 58 nM。SR-4113对膀胱癌症细胞表现出纳摩尔级的生长抑制作用，抑制 T24 细胞中 4E-BP1 磷酸化。

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SR-4133 Chemical Structure

SR-4133 Chemical Structure

CAS No. : 2999645-23-5

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SR-4133 相关抗体

Top Publications Citing Use of Products

查看 Casein Kinase 亚型特异性产品:

查看所有亚型
CK1 CK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SR-4133 is a potent and highly CK1ε selective inhibitor with an IC50 of 58 nM. SR-4133 binds to the ATP-binding site of CK1ε. SR-4133 displays nanomolar growth inhibition of bladder cancer cells, and inhibits the phosphorylation of 4E-BP1[1].

IC50 & Target

CK1ε

58 nM (IC50)

CK1δ

10 μM (IC50)

体外研究
(In Vitro)

SR-4133 (200-600 nM，72 小时) 显著抑制癌细胞生长， T24 EC50 为 265 nM， 5637 EC50 为 314 nM， UM-UC-3 EC50 为 540 nM， U2-OS EC50 为 373 nM[1]。
SR-4133 (1 μM，24 h) 抑制 T24 细胞中 4E-BP1 磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SR-4133 相关抗体:

Cell Viability Assay[1]

Cell Line: T24, 5637, UM-UC-3, U2-OS
Concentration: 265 nM, 314 nM, 540 nM, 373 nM
Incubation Time: 72 h
Result: Inhibited cell growth with EC50s of 265 nM (T24), 314 nM (5637), 540 nM (UM-UC-3 EC), 373 nM (U2-OS EC).

Western Blot Analysis[1]

Cell Line: T24
Concentration: 1 μM
Incubation Time: 24 h
Result: Blocked the phosphorylation of T37/46, S65, and T70 of 4E-BP1.
分子量

512.51

Formula

C27H22F2N8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SR-4133 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR-41332999645-23-5SR4133SR 4133Casein KinaseT245637UM-UC-3U2-OSbladder cancerInhibitorinhibitorinhibit

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目录号：
HY-149292
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