2. Apoptosis
  3. Apoptosis
  4. TACC3 inhibitor 1

TACC3 inhibitor 1 是一种有效的，可透过血脑屏障的 TACC3 抑制剂。TACC3 inhibitor 1 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 G2/M 期。TACC3 inhibitor 1 诱导细胞内 ROS 的产生。TACC3 inhibitor 1 具有抗增殖和抗肿瘤活性。

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TACC3 inhibitor 1 Chemical Structure

TACC3 inhibitor 1 Chemical Structure

CAS No. : 3033646-06-6

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TACC3 inhibitor 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TACC3 inhibitor 1 is a potent and cross the blood-brain barrier TACC3 inhibitor. TACC3 inhibitor 1 induces Apoptosis and cell cycle arrest at G2/M phase. TACC3 inhibitor 1 induces the generation of intracellular ROS. TACC3 inhibitor 1 shows antiproliferative and anti-tumor activity[1].

体外研究
(In Vitro)

TACC3 inhibitor 1 (compound 7g) (1, 2, 4 µM; 36 h) 诱导细胞凋亡和细胞周期停滞在 G2/M 期[1]。
TACC3 inhibitor 1 (1, 2, 4 µM; 36 h) 降低线粒体膜电位并诱导细胞内 ROS 的产生[1]。
TACC3 inhibitor 1 (1, 2, 4 µM; 24 h) 抑制 U87 细胞的迁移和侵袭[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TACC3 inhibitor 1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: U251, U87, MDA-MB-231, JIMT-1, SKOV-3, HLF-1 cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Showed antiproliferative activities with IC50s of 5.61, 3.29, 6.46, 4.84, 8.21, 23.11 µM for U251, U87, MDA-MB-231, JIMT-1, SKOV-3, HLF-1 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: U87 cells
Concentration: 1, 2, 4 µM
Incubation Time: 36 h
Result: Induced cell cycle arrest at G2/M phase with the 41.2% cells at G2/M phase at 4 µM.

Apoptosis Analysis[1]

Cell Line: U87 cells
Concentration: 1, 2, 4 µM
Incubation Time: 36 h
Result: Induced apoptosis in a dose-dependent manner with the percentage of early apoptotic cells increased from 4.49% in control group to 21.42%, late apoptotic cells increased from 0.52% to 26.72% at 4 µM.
体内研究
(In Vivo)

TACC3 inhibitor 1 (20 mg/kg; i.p.; daily for 20 days) 在小鼠体内显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old BALB/c nude mice (U87 xenograft model)[1]
Dosage: 20 mg/kg
Administration: I.p.; daily for 20 days
Result: Exhibited a significant tumor growth regression and no observable toxicity during the administration period and had no effects on the body weight.
分子量

379.48

Formula

C20H21N5OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TACC3 inhibitor 1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TACC3 inhibitor 13033646-06-6Apoptosiscross the blood-brain barrierantiproliferativeanti-tumorapoptosisG2/M phasemigrationinvasionU87 cellsInhibitorinhibitorinhibit

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