2. Apoptosis
  3. Apoptosis
  4. Taccalonolide E

Taccalonolide E  (Synonyms: 根薯酮内酯E)

目录号: HY-N11067
产品使用指南

摩尔计算器

Taccalonolide E 是一种微管稳定剂，诱导癌细胞凋亡 (apoptosis)。

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Taccalonolide E Chemical Structure

Taccalonolide E Chemical Structure

CAS No. : 134954-57-7

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Taccalonolide E 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
39.5 μM
Compound: Taccalonolide E
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
[PMID: 23855953]
HeLa IC50
39500 nM
Compound: 7
Antiproliferative activity against human HeLa cells by SRB assay
Antiproliferative activity against human HeLa cells by SRB assay
[PMID: 24959756]
HeLa IC50
644 nM
Compound: 3
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
[PMID: 21800839]
体外研究
(In Vitro)

Taccalonolide E (5 or 10 μM; 18 h) 在 A-10 细胞中导致间期细胞中细胞微管密度增加，形成厚束微管[1]。
Taccalonolide E (1 or 5 μM; 18 h) 导致 A-10 和 HeLa 细胞出现异常多极有丝分裂纺锤体[1]。
Taccalonolide E (5 μM; 6-24 h) 在 G2-M 期阻滞细胞周期[1]。
Taccalonolide E (0.5-5 μM; 18 h) 在间期细胞中启动微核化[1]。
Taccalonolide E (48 h) 抑制癌细胞增殖[1]。
Taccalonolide E (10 μM; 1 h) 导致 MDA-MB-435 细胞微管蛋白聚合[1]。
Taccalonolide E (5 μM; 4-30 h) 启动 Bcl-2 磷酸化，MAPK 激活和凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Taccalonolide E 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MDA-MB-435 cells
Concentration: 5 μM
Incubation Time: 6, 12, 18, or 24 h
Result: Caused cells to accumulate in the G2-M phase of the cell cycle.

Cell Proliferation Assay[1]

Cell Line: SK-OV-3, MDA-MB-435, NCI/ADR, 1 A9, PTX 10, PTX 22 and 1A9/A8 cells
Concentration:
Incubation Time: 48 h
Result: Inhibited the proliferation with IC50s of 0.99 ± 0.08, 0.78 ± 0.17, 21.1 ± 0.46, 0.34 ± 0.04, 1.64 ± 0.25, 4.01 ± 0.20 and 1.42 ± 0.30 μM against SK-OV-3, MDA-MB-435, NCI/ADR, 1 A9, PTX 10, PTX 22 and 1A9/A8 cells, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-435 cells
Concentration: 5 μM
Incubation Time: 4, 6, 12, 24, or 30 h
Result: Activated ERK1/2 and increased PARP cleavage.
分子量

644.71

Formula

C34H44O12
CAS 号
中文名称

根薯酮内酯E
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Taccalonolide E 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taccalonolide E134954-57-7根薯酮内酯EApoptosisA-10Bcl-2 phosphorylationMAPKMDA-MB-435Inhibitorinhibitorinhibit

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