2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. TAK-637

TAK-637 是一种具有口服活性的神经激肽-1 受体 (neurokinin-1 receptor) 拮抗剂。TAK-637 可增加膀胱储存容量。TAK-637 可用于研究功能性肠道疾病，例如肠易激综合征。

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TAK-637 Chemical Structure

TAK-637 Chemical Structure

CAS No. : 217185-75-6

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TAK-637 相关抗体

Top Publications Citing Use of Products

查看 Neurokinin Receptor 亚型特异性产品:

查看所有亚型
NK1 NK2 NK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TAK-637 is an orally active neurokinin-1 receptor antagonist. TAK-637 increases bladder storage capacity. TAK-637 can be used for research of functional bowel diseases such as irritable bowel syndrome[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
IM-9 IC50
0.45 nM
Compound: 19, TAK-637
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
[PMID: 21807525]
分子量

573.53

Formula

C30H25F6N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TAK-637 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAK-637217185-75-6TAK637TAK 637Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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产品名称：
TAK-637
目录号：
HY-105534
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