2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. GABA Receptor Endogenous Metabolite
  4. Tetrahydrodeoxycorticosterone

Tetrahydrodeoxycorticosterone  (Synonyms: Tetrahydro-11-deoxycorticosterone)

目录号: HY-113346 纯度: 99.45%
COA 产品使用指南

摩尔计算器

Tetrahydrodeoxycorticosterone 是一种神经类固醇，是一种有效的 GABAA 受体正变构调节剂 (PAM)。Tetrahydrodeoxycorticosterone 具有有效的神经抑制特性。

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Tetrahydrodeoxycorticosterone Chemical Structure

Tetrahydrodeoxycorticosterone Chemical Structure

CAS No. : 567-03-3

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规格 价格 是否有货 数量
1 mg ￥2300
In-stock
5 mg ￥5800
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Other Forms of Tetrahydrodeoxycorticosterone:

Tetrahydrodeoxycorticosterone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

The endogenous neurosteroid Tetrahydrodeoxycorticosterone (THDOC) at physiological concentrations selectively enhances tonic currents mediated by αβδ receptors[1].
In hippocampus, 10 nM Tetrahydrodeoxycorticosterone reduces neuronal excitability by augmenting tonic αβδ receptor currents. In thalamocortical neurons, although 100 nM Tetrahydrodeoxycorticosterone enhances tonic currents, 10 nM Tetrahydrodeoxycorticosterone does not[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrahydrodeoxycorticosterone 相关抗体:
体内研究
(In Vivo)

Concentrations of Tetrahydrodeoxycorticosterone (THDOC) in brain tissue from mice with hepatic encephalopathy (HE) resulting from toxic liver injury are sufficient to induce sedation in animals of the same species[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

334.49

Formula

C21H34O3
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (298.96 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9896 mL 14.9481 mL 29.8963 mL
5 mM 0.5979 mL 2.9896 mL 5.9793 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.45%

COA (289 KB)

产品使用指南 (1538 KB)
参考文献

Tetrahydrodeoxycorticosterone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9896 mL 14.9481 mL 29.8963 mL 74.7407 mL
5 mM 0.5979 mL 2.9896 mL 5.9793 mL 14.9481 mL
10 mM 0.2990 mL 1.4948 mL 2.9896 mL 7.4741 mL
15 mM 0.1993 mL 0.9965 mL 1.9931 mL 4.9827 mL
20 mM 0.1495 mL 0.7474 mL 1.4948 mL 3.7370 mL
25 mM 0.1196 mL 0.5979 mL 1.1959 mL 2.9896 mL
30 mM 0.0997 mL 0.4983 mL 0.9965 mL 2.4914 mL
40 mM 0.0747 mL 0.3737 mL 0.7474 mL 1.8685 mL
50 mM 0.0598 mL 0.2990 mL 0.5979 mL 1.4948 mL
60 mM 0.0498 mL 0.2491 mL 0.4983 mL 1.2457 mL
80 mM 0.0374 mL 0.1869 mL 0.3737 mL 0.9343 mL
100 mM 0.0299 mL 0.1495 mL 0.2990 mL 0.7474 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrahydrodeoxycorticosterone567-03-3Tetrahydro-11-deoxycorticosteroneGABA ReceptorEndogenous MetaboliteGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAAneurosteroidneuroinhibitorysedationInhibitorinhibitorinhibit

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目录号：
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