2. Cell Cycle/DNA Damage Epigenetics Cytoskeleton
  3. PAK HDAC
  4. ZMF-23

ZMF-23 是一种 PAK1/HDAC6 双重抑制剂。ZMF-23 抑制 PAK1 和 HDAC6 调节的有氧糖酵解和迁移。ZMF-23 诱导 TNF-α 调节的坏死性凋亡 (necroptosis)，并进一步增强细胞凋亡 (apoptosis)。ZMF-23 抑制 Warburg 效应和细胞迁移。ZMF-23 可用于三阴性乳腺癌 (TNBC) 的研究。

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ZMF-23 Chemical Structure

ZMF-23 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Customer Review

ZMF-23 相关抗体

Top Publications Citing Use of Products

查看 PAK 亚型特异性产品:

查看所有亚型
PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZMF-23 is a PAK1/HDAC6 dual inhibitor. ZMF-23 inhibits PAK1 and HDAC6 regulated aerobic glycolysis and migration. ZMF-23 induces TNF-α-regulated necroptosis, and further enhances apoptosis. ZMF-23 inhibits the Warburg effect and cell migration. ZMF-23 can be used for research of triple-negative breast cancer (TNBC)[1].

IC50 & Target

HDAC6[1]
分子量

476.36

Formula

C22H23Cl2N5O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZMF-23 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZMF-23ZMF23ZMF 23PAKHDACp21 activated kinasesHistone deacetylasesTriple-negative breast cancerTNBCTNF-αWarburg effectInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-155179
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