4-Methoxychalcone-1 (Synonyms: 4-甲氧基查耳酮)

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摩尔计算器

4-Methoxychalcone 是一种天然存在的查尔酮类化合物。4-Methoxychalcone 具有抗氧化活性，抗炎活性，抗肿瘤活性和抗菌活性。4-Methoxychalcone 可用于对炎症以及肿瘤模型的研究。

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4-Methoxychalcone-1 Chemical Structure

CAS No. : 959-33-1

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生物活性

4-Methoxychalcone is a naturally occurring chalcone compound. 4-Methoxychalcone has antioxidant activity, anti-inflammatory activity, antitumor activity and antibacterial activity. 4-Methoxychalcone can be used to study inflammation and tumor models^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A2780	GI₅₀	14.4 μM Compound: 9	Antiproliferative activity against human A2780 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay Antiproliferative activity against human A2780 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay	[PMID: 34262643]
CAL-51	GI₅₀	2.69 μM Compound: SSE14106	Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay	[PMID: 28743509]
DLD-1	EC₅₀	52 μM Compound: 9	Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
FHC	CC₅₀	99 μM Compound: 9	Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
HCT-116	EC₅₀	22 μM Compound: 9	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
HCT-116	GI₅₀	3.86 μM Compound: SSE14106	Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay	[PMID: 28743509]
HCT-116	EC₅₀	30 μM Compound: 9	Cytotoxicity against p53-/- human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against p53-/- human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
HepG2	IC₅₀	> 100 μM Compound: 4	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 22658085]
HK-2	IC₅₀	23.2 μM Compound: 5	Growth inhibition of HK2 cells by sulforhodamine assay Growth inhibition of HK2 cells by sulforhodamine assay	[PMID: 17383189]
HT-29	GI₅₀	16.7 μM Compound: 9	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay	[PMID: 34262643]
HT-29	EC₅₀	32 μM Compound: 9	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay	[PMID: 36356534]
HT-29	IC₅₀	54 μM Compound: 5	Growth inhibition of HT29 cells by sulforhodamine assay Growth inhibition of HT29 cells by sulforhodamine assay	[PMID: 17383189]
K562	IC₅₀	29 μM Compound: 4-Methoxychalcone	Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay	[PMID: 24775915]
MCF7	IC₅₀	90 μM Compound: 5	Growth inhibition of MCF7 cells by sulforhodamine assay Growth inhibition of MCF7 cells by sulforhodamine assay	[PMID: 17383189]
MSTO-211H	GI₅₀	10.4 μM Compound: 9	Antiproliferative activity against human MSTO-211H cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay Antiproliferative activity against human MSTO-211H cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay	[PMID: 34262643]
TK-10	IC₅₀	53 μM Compound: 5	Growth inhibition of TK10 cells by sulforhodamine assay Growth inhibition of TK10 cells by sulforhodamine assay	[PMID: 17383189]

分子量

238.28

Formula

C₁₆H₁₄O₂

CAS 号

959-33-1

中文名称

4-甲氧基查耳酮

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Basudan O A, et al. Note: a new chromone from Ficus lyrata[J]. Journal of Asian natural products research, 2005, 7(1): 81-85. [Content Brief]

4-Methoxychalcone-1 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Methoxychalcone-1959-33-14-甲氧基查耳酮OthersNatural compoundsantioxidantanti-inflammatoryanti-tumorantibacterialInhibitorinhibitorinhibit

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4-Methoxychalcone-1 (Synonyms: 4-甲氧基查耳酮)

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4-Methoxychalcone-1 (Synonyms: 4-甲氧基查耳酮)

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