2. Metabolic Enzyme/Protease
  3. Neprilysin
  4. Candoxatril

Candoxatril  (Synonyms: UK 79300)

目录号: HY-19649
COA 产品使用指南

摩尔计算器

Candoxatril 是中性肽链内切酶 (NEP) 的一个抑制剂。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Candoxatril Chemical Structure

Candoxatril Chemical Structure

CAS No. : 123122-55-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货
1 mg ￥3185
询问价格 & 货期
5 mg 现货 询问价格 & 货期

* Please select Quantity before adding items.

Customer Review

Candoxatril 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Candoxatril is a neutral endopeptidase (NEP) inhibitor.

IC50 & Target

NEP[1].
体内研究
(In Vivo)

While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

515.64

Formula

C29H41NO7
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (96.97 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9393 mL 9.6967 mL 19.3934 mL
5 mM 0.3879 mL 1.9393 mL 3.8787 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[2]

Mice[2]
Mice (n=10 per group) subjected to UUO are treated for 1 week with either Solvent, SOL-1 (NEP-/ECE-inhibitor two doses), Candoxatril (reference NEP inhibitor) or losartan (angiotensin AT1-receptor antagonist) and compared to sham operated animals[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Candoxatril 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9393 mL 9.6967 mL 19.3934 mL 48.4834 mL
5 mM 0.3879 mL 1.9393 mL 3.8787 mL 9.6967 mL
10 mM 0.1939 mL 0.9697 mL 1.9393 mL 4.8483 mL
15 mM 0.1293 mL 0.6464 mL 1.2929 mL 3.2322 mL
20 mM 0.0970 mL 0.4848 mL 0.9697 mL 2.4242 mL
25 mM 0.0776 mL 0.3879 mL 0.7757 mL 1.9393 mL
30 mM 0.0646 mL 0.3232 mL 0.6464 mL 1.6161 mL
40 mM 0.0485 mL 0.2424 mL 0.4848 mL 1.2121 mL
50 mM 0.0388 mL 0.1939 mL 0.3879 mL 0.9697 mL
60 mM 0.0323 mL 0.1616 mL 0.3232 mL 0.8081 mL
80 mM 0.0242 mL 0.1212 mL 0.2424 mL 0.6060 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Candoxatril123122-55-4UK 79300UK79300UK-79300NeprilysinNeutral endopeptidaseNEPCluster of differentiation 10CD10Inhibitorinhibitorinhibit

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目录号：
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