2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Hemokinin 1 (mouse)

Hemokinin 1 (mouse) 

目录号: HY-P1030 纯度: 99.49%
COA 产品使用指南

摩尔计算器

Hemokinin 1 (mouse) 是一种选择性的神经激肽-1 受体 (neurokinin 1 receptor) 激动剂，对人 NK1 受体和 NK2 受体的 Ki 分别为 0.175 nM 和 560 nM。

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Hemokinin 1 (mouse) Chemical Structure

Hemokinin 1 (mouse) Chemical Structure

CAS No. : 208041-90-1

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规格 价格 是否有货 数量
1 mg ￥700
In-stock
5 mg ￥1700
In-stock
10 mg ￥2700
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Hemokinin 1 (mouse) 相关抗体

Top Publications Citing Use of Products

查看 Neurokinin Receptor 亚型特异性产品:

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NK1 NK2 NK3

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

IC50 & Target

Ki: 0.175 nM (Human NK1 receptor), 560 nM (Human NK2 receptor)[1]
体外研究
(In Vitro)

Hemokinin 1 (mouse) (1 nM-3 μM) produces concentration-dependent contraction of RUB averaging 66±3% (n=6) of the maximal contraction produced by KCl (80 mM). Hemokinin 1 (mouse) (10 nM-10 μM) induces a quickly-developing contractile responses of GPI, as does the tachykinin NK3 receptor selective agonist senktide or neurokinin B (NKB). Hemokinin 1 (mouse) induces full agonist responses but with a 500 fold lower potency as compared to NKB[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hemokinin 1 (mouse) 相关抗体:
体内研究
(In Vivo)

Hemokinin 1 (mouse) (0.01-100 nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10 nmol/kg. For systolic blood pressure (SBP), the ED50 value is 0.2 nmol/kg (0.1-0.4 nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED50 value is 0.1 nmol/kg (0.07-0.2 nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100 nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1413.65

Formula

C61H100N22O15S
CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

RSRTRQFYGLM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Stored under nitrogen, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (70.74 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7074 mL 3.5369 mL 7.0739 mL
5 mM 0.1415 mL 0.7074 mL 1.4148 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

Male albino Wistar Rats weighing 400-450 g are used throughout the study. On the day of the experiment, rats are anaesthetized with urethane (1.2 g/kg, s.c.). Following tracheotomy and placement of a tracheal cannula (PE 205), the left jugular vein is cannulated (PE50) for SP or Hemokinin 1 (mouse) administrations. The body temperature is maintained constant (36.5±0.5°C) by a thermoregulated heating lamp. About 1 h elapsed between the animal set-up and the start of the experiments, thereafter each animal receive atropine (1.4 μmol/kg i.v. as bolus followed by infusion of 1.4 μM in a volume of 300 μL/h) and 10 min later the vehicle (saline) and increasing doses (0.5 log units) of SP or Hemokinin 1 (mouse) (0.01, 0.03, 0.1, 0.3, 1, 3, 10, 30, and 100 nmol/kg); the first five doses are administered at 20 min intervals, whereas 30 min elapsed between each of the last four doses. Atropine pretreatment is performed in order to minimize the influence of cholinergic secretory reflexes in response to the placement of the cotton swab in the rat's oral cavity for the measurement of salivary secretion induced by SP or Hemokinin 1 (mouse).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Hemokinin 1 (mouse) 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7074 mL 3.5369 mL 7.0739 mL 17.6847 mL
5 mM 0.1415 mL 0.7074 mL 1.4148 mL 3.5369 mL
10 mM 0.0707 mL 0.3537 mL 0.7074 mL 1.7685 mL
15 mM 0.0472 mL 0.2358 mL 0.4716 mL 1.1790 mL
20 mM 0.0354 mL 0.1768 mL 0.3537 mL 0.8842 mL
25 mM 0.0283 mL 0.1415 mL 0.2830 mL 0.7074 mL
30 mM 0.0236 mL 0.1179 mL 0.2358 mL 0.5895 mL
40 mM 0.0177 mL 0.0884 mL 0.1768 mL 0.4421 mL
50 mM 0.0141 mL 0.0707 mL 0.1415 mL 0.3537 mL
60 mM 0.0118 mL 0.0589 mL 0.1179 mL 0.2947 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hemokinin 1 (mouse)208041-90-1Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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