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  4. Melinamide

Melinamide  (Synonyms: 甲亚油酰胺; AC 223; DL-N-(α-Methylbenzyl)linoleamide)

目录号: HY-101722 纯度: 99.94%
COA 产品使用指南

摩尔计算器

Melinamide是不饱和长链脂肪酸的酰胺衍生物。它是胆固醇吸收的抑制剂，IC50值为20.9 μM。

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Melinamide Chemical Structure

Melinamide Chemical Structure

CAS No. : 14417-88-0

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2200
In-stock
1 mg ￥909
In-stock
5 mg ￥2000
In-stock
10 mg ￥3500
In-stock
25 mg ￥6000
In-stock
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

Melinamide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC50 of 20.9 μM.

IC50 & Target

IC50: 20.9 μM (cholesterol)[1]
体外研究
(In Vitro)

DL-Melinamide inhibits acyl CoA:cholesterol acyltransferase activity (ACAT) in the mucosal microsomes, with 50% inhibition occurring at approximately 0.5 μM. Kinetic studies indicate that DL-Melinamide is an uncompetitive inhibitor of acyl CoA:cholesterol acyltransferase. D-Melinamide is found to be a more effective inhibitor than L-Melinamide[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Melinamide 相关抗体:
体内研究
(In Vivo)

Melinamide is a new hypocholesterolaemic drug. Melinamide causes a substantial decrease of the enhanced intestinal ACAT activity in diabetic rats, but does not affect intestinal cholesterol esterase activity. Furthermore, marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurrs concomitantly with the drug treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

383.61

Formula

C26H41NO
CAS 号
性状

油状物

颜色

Colorless to light yellow

中文名称

甲亚油酰胺；甲亚油脂酰胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 200 mg/mL (521.36 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6068 mL 13.0341 mL 26.0681 mL
5 mM 0.5214 mL 2.6068 mL 5.2136 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[3]

Rats: 10 diabetic rats are divided into two groups: a cholesterol-fed diabetic group and a melinamide-treated cholesterol-fed diabetic group. Five control rats are injected with citrate buffer only. The rats are fed each diet for 3 weeks after injection. The chol-fed DM group receives a diet (20 g/day) containing 1% cholesterol, 0.5% cholic acid and 5% lard. The melinamide-treated group receives the same diet but supplemented with 0.1% melinamide. Control rats are fed a standard chow (20 g/day). Following a 24-h fast the animals are killed. Blood is collected by aortic puncture and samples of small intestine are retained[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Melinamide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6068 mL 13.0341 mL 26.0681 mL 65.1704 mL
5 mM 0.5214 mL 2.6068 mL 5.2136 mL 13.0341 mL
10 mM 0.2607 mL 1.3034 mL 2.6068 mL 6.5170 mL
15 mM 0.1738 mL 0.8689 mL 1.7379 mL 4.3447 mL
20 mM 0.1303 mL 0.6517 mL 1.3034 mL 3.2585 mL
25 mM 0.1043 mL 0.5214 mL 1.0427 mL 2.6068 mL
30 mM 0.0869 mL 0.4345 mL 0.8689 mL 2.1723 mL
40 mM 0.0652 mL 0.3259 mL 0.6517 mL 1.6293 mL
50 mM 0.0521 mL 0.2607 mL 0.5214 mL 1.3034 mL
60 mM 0.0434 mL 0.2172 mL 0.4345 mL 1.0862 mL
80 mM 0.0326 mL 0.1629 mL 0.3259 mL 0.8146 mL
100 mM 0.0261 mL 0.1303 mL 0.2607 mL 0.6517 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Melinamide14417-88-0AC 223 DL-N-(α-Methylbenzyl)linoleamide甲亚油酰胺甲亚油脂酰胺AC223AC-223OthersInhibitorinhibitorinhibit

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