2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Tetracaine hydrochloride

Tetracaine hydrochloride  (Synonyms: 盐酸丁卡因; Amethocaine hydrochloride)

目录号: HY-B0473 纯度: 99.91%
COA 产品使用指南

摩尔计算器

Tetracaine hydrochloride (Amethocaine hydrochloride) 是一种钙通道蛋白抑制剂，可阻断肌浆网中Ca2+ 的电压敏感释放。Tetracaine hydrochloride 主要用于眼科和止痒药。

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Tetracaine hydrochloride Chemical Structure

Tetracaine hydrochloride Chemical Structure

CAS No. : 136-47-0

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规格 价格 是否有货 数量
50 mg ￥66
In-stock
500 mg ￥200
In-stock
1 g ￥300
In-stock
5 g   询价  
10 g   询价  

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Customer Review

Other Forms of Tetracaine hydrochloride:

Tetracaine hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO-K1 IC50
0.53 μM
Compound: tetracaine
Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
CHO-K1 IC50
1.1 μM
Compound: tetracaine
Inhibition of human NaV1.2 alpha subunit expressed in CHOK1 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.2 alpha subunit expressed in CHOK1 cells at -65 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
0.11 μM
Compound: tetracaine
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
0.49 μM
Compound: Tetracaine
Inhibition of recombinant human Nav1.2 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay
Inhibition of recombinant human Nav1.2 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay
[PMID: 27015369]
HEK293 IC50
0.52 μM
Compound: Tetracaine
Inhibition of recombinant human Nav1.6 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay
Inhibition of recombinant human Nav1.6 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay
[PMID: 27015369]
HEK293 IC50
0.62 μM
Compound: tetracaine
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assay
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
0.65 μM
Compound: Tetracaine
Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp method
Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp method
[PMID: 27015369]
HEK293 IC50
0.74 μM
Compound: Tetracaine
Inhibition of recombinant human Nav1.3 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay
Inhibition of recombinant human Nav1.3 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay
[PMID: 27015369]
HEK293 IC50
33 μM
Compound: tetracaine
Inhibition of human NaV1.7 F1737A mutant expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.7 F1737A mutant expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
7.51 μM
Compound: Tetracaine
Inhibition of human NaV1.7 expressed in HEK293 cells by [14C]guanidinium influx assay
Inhibition of human NaV1.7 expressed in HEK293 cells by [14C]guanidinium influx assay
[PMID: 21570288]
体外研究
(In Vitro)

Tetracaine hydrochloride (Amethocaine hydrochloride) is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine hydrochloride is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tetracaine hydrochloride 相关抗体:
分子量

300.82

Formula

C15H25ClN2O2
CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸丁卡因；潘托卡因
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
细胞实验： 

H2O 中的溶解度 : 50 mg/mL (166.21 mM; 超声助溶)

DMSO 中的溶解度 : ≥ 30 mg/mL (99.73 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3242 mL 16.6212 mL 33.2425 mL
5 mM 0.6648 mL 3.3242 mL 6.6485 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.91%

COA (284 KB) LCMS (84 KB)

产品使用指南 (1538 KB)
参考文献

Tetracaine hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.3242 mL 16.6212 mL 33.2425 mL 83.1062 mL
5 mM 0.6648 mL 3.3242 mL 6.6485 mL 16.6212 mL
10 mM 0.3324 mL 1.6621 mL 3.3242 mL 8.3106 mL
15 mM 0.2216 mL 1.1081 mL 2.2162 mL 5.5404 mL
20 mM 0.1662 mL 0.8311 mL 1.6621 mL 4.1553 mL
25 mM 0.1330 mL 0.6648 mL 1.3297 mL 3.3242 mL
30 mM 0.1108 mL 0.5540 mL 1.1081 mL 2.7702 mL
40 mM 0.0831 mL 0.4155 mL 0.8311 mL 2.0777 mL
50 mM 0.0665 mL 0.3324 mL 0.6648 mL 1.6621 mL
60 mM 0.0554 mL 0.2770 mL 0.5540 mL 1.3851 mL
80 mM 0.0416 mL 0.2078 mL 0.4155 mL 1.0388 mL
H2O 100 mM 0.0332 mL 0.1662 mL 0.3324 mL 0.8311 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetracaine136-47-0Amethocaine盐酸丁卡因潘托卡因Calcium ChannelCa2+ channelsCa channelscalciumchannelproteinvoltage-sensitivereleaseCa2+sarcoplasmicreticulumInhibitorinhibitorinhibit

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目录号：
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