2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. U-46619

U-46619  (Synonyms: 9,11-Methanoepoxy PGH2)

目录号: HY-108566 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

U-46619 (9,11-Methanoepoxy PGH2) 是一种稳定的 Thromboxane A2 (HY-113350) (TXA2) 的类似物，可作为有效的 TXA2 (TP) 激动剂。 U-46619 也是一种 RhoA 激动剂。 U-46619 通过 TXA2 受体激活来刺激 RhoA 的激活。

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U-46619 Chemical Structure

U-46619 Chemical Structure

CAS No. : 56985-40-1

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规格 价格 是否有货 数量
1 mg (28.5 mM * 100 μL in Methyl acetate) ￥3300
In-stock
5 mg (28.5 mM * 500 μL in Methyl acetate) 现货 询价

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Customer Review

U-46619 相关抗体

Top Publications Citing Use of Products

查看 Prostaglandin Receptor 亚型特异性产品:

查看所有亚型
DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation[1][4][5].

IC50 & Target

TXA2/TP

 

体外研究
(In Vitro)

U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC50s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively[1].
? U-46619 (10 nM-10 μM) increases internal Ca2+ concentration ([Ca2+]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency[1].
? U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets[1].
? U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

U-46619 相关抗体:
体内研究
(In Vivo)

U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 12-15 weeks-old male and female SHR[2]
Dosage: 5 μg/kg
Administration: Intravenous injection
Result: Induceed a significant increase of MABP after 1 min in male SHR.
分子量

350.49

Formula

C21H34O4
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (285.31 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (287 KB)

产品使用指南 (1538 KB)
参考文献

U-46619 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8531 mL 14.2657 mL 28.5315 mL 71.3287 mL
5 mM 0.5706 mL 2.8531 mL 5.7063 mL 14.2657 mL
10 mM 0.2853 mL 1.4266 mL 2.8531 mL 7.1329 mL
15 mM 0.1902 mL 0.9510 mL 1.9021 mL 4.7552 mL
20 mM 0.1427 mL 0.7133 mL 1.4266 mL 3.5664 mL
25 mM 0.1141 mL 0.5706 mL 1.1413 mL 2.8531 mL
30 mM 0.0951 mL 0.4755 mL 0.9510 mL 2.3776 mL
40 mM 0.0713 mL 0.3566 mL 0.7133 mL 1.7832 mL
50 mM 0.0571 mL 0.2853 mL 0.5706 mL 1.4266 mL
60 mM 0.0476 mL 0.2378 mL 0.4755 mL 1.1888 mL
80 mM 0.0357 mL 0.1783 mL 0.3566 mL 0.8916 mL
100 mM 0.0285 mL 0.1427 mL 0.2853 mL 0.7133 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U-4661956985-40-19,11-Methanoepoxy PGH2U46619U 46619Prostaglandin ReceptorTXA2plateletsshapechangeaggregationrat cerebrovascular endothelial cellsPC-3 cellInhibitorinhibitorinhibit

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目录号：
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