2. Anti-infection Apoptosis
  3. HBV Apoptosis
  4. Alisol F 24-acetate

Alisol F 24-acetate 是一种三萜化合物，可从东方泽泻的根茎中分离。Alisol F 24-acetate 抑制 HBV 表面抗原 HBsAg 和 HBeAg 的分泌，IC50 值分别为 7.7 µM 和 5.1 µM。Alisol F 24-acetate 具有促凋亡活性，可用于癌症研究。

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Alisol F 24-acetate Chemical Structure

Alisol F 24-acetate Chemical Structure

CAS No. : 443683-76-9

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Alisol F 24-acetate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC50 values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 EC50
25.29 μM
Compound: 46
Transactivation of FXR (unknown origin) transfected in HepG2 cells co-expressing pBSEP/pGL4.74 incubated for 24 hrs by luciferase reporter gene assay
Transactivation of FXR (unknown origin) transfected in HepG2 cells co-expressing pBSEP/pGL4.74 incubated for 24 hrs by luciferase reporter gene assay
[PMID: 31494470]
体外研究
(In Vitro)

Alisol F 24-acetate (5、10 和 20 µM；24 h) 在 MCF-7/DOX 细胞中以剂量依赖性方式增加了阿霉素 (Doxorubicin，HY-15142A) 的化学敏感性[2]。
Alisol F 24-acetate (5、10 和 20 µM) 在 MCF-7/DOX 细胞中以剂量依赖性方式增加了阿霉素的积累。Alisol F 24-acetate (10 µM) 在 Caco-2 细胞单层中增加了地高辛 (Digoxin，HY-B1049) 的吸收 (AP-BL)，降低了地高辛的分泌 (BL-AP)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Alisol F 24-acetate 相关抗体:

Cell Viability Assay[2]

Cell Line: Caco-2 cells and MCF-7/DOX cells.
Concentration: 1, 2, 5, 10, 20, 50 and 100 µM.
Incubation Time: 24 h.
Result: Significantly inhibited the cell viability (100 µM).

Apoptosis Analysis[2]

Cell Line: MCF-7/DOX cells.
Concentration: 5, 10 and 20 µM.
Incubation Time: 0.5, 1, 2, 3 and 4 h.
Result: Promoted the doxorubicin-induced apoptosis with time and dose dependent manner.
分子量

530.74

Formula

C32H50O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Alisol F 24-acetate 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Alisol F 24-acetate443683-76-9HBVApoptosisHepatitis B virusAlisma orientalisInhibitorinhibitorinhibit

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