2. PI3K/Akt/mTOR Membrane Transporter/Ion Channel
  3. PI4K Potassium Channel
  4. Antimalarial agent 41

Antimalarial agent 41 (Compound 17) 具有抗疟活性，可抑制恶性疟原虫 Plasmodium falciparum，IC50 为 40 nM (NF54 株) 和 76 nM (K1 株)。Antimalarial agent 41 是 P. falciparum 磷脂酰肌醇-4-激酶 β (Pf PI4K) 和 hERG 通道的抑制剂，IC50 为 53 nM 和 3 μM。Antimalarial agent 41 对 CHO 细胞具有细胞毒性，IC50 为 34 μM。Antimalarial agent 41 可改善疟疾感染，并在小鼠模型中表现出良好的药代动力学特征。

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Antimalarial agent 41 Chemical Structure

Antimalarial agent 41 Chemical Structure

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Antimalarial agent 41 相关抗体

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查看 PI4K 亚型特异性产品:

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PI4KIIIβ PI4KIIIα PI4K PI4KII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC50 of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC50 of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC50 of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models[1].

IC50 & Target

Pf PI4K

53 nM (IC50)

分子量

373.37

Formula

C19H18F3N5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antimalarial agent 41 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 41Antimalarial agent41Antimalarial agent-41PI4KPotassium ChannelPhosphatidylinositol 4 kinasesPI4 kinasesKcsAPlasmodium falciparumNSG mouseantimalarialInhibitorinhibitorinhibit

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