2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC Histone Methyltransferase
  4. BG47

BG47 是一种典型的组蛋白脱乙酰酶 HDAC1 或 HDAC2 选择性光表观遗传学探针，在光诱导的反式-顺式异构化时能与 HDAC 靶点结合并竞争性抑制其脱乙酰酶活性，增加组蛋白甲基转移酶 (Histone Methyltransferase) H3K9 乙酰化。BG47 可用于神经性疾病研究。

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BG47 Chemical Structure

BG47 Chemical Structure

CAS No. : 1628784-54-2

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Other Forms of BG47:

BG47 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. BG47 can be used for neurological disease research[1].

IC50 & Target[1]

HDAC1

 

HDAC2

 

体外研究
(In Vitro)

BG47 (10 μM，16 小时) 在光存在 (开 25 ms/关 75 ms) 情况下使人神经元前体细胞 (NPCs) 中 H3K9 乙酰化升高，并显著上调前颗粒蛋白 (PGRN) 表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BG47 相关抗体:

Immunofluorescence[1]

Cell Line: Human neural progenitor cells (NPCs)
Concentration: 10 μM
Incubation Time: 16 hours
Result: Elevated H3K9 acetylation and significantly upregulated PGRN expression only in the presence of light (25 ms on/75 ms off).
分子量

442.53

Formula

C25H22N4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BG47 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BG471628784-54-2BG 47BG-47HDACHistone MethyltransferaseHistone deacetylasesHDAC1 inhibitorHDAC2 inhibitorHuman NPCsNeurological DiseaseInhibitorinhibitorinhibit

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产品名称：
BG47
目录号：
HY-117583A
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