2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Prostaglandin Receptor Lipoxygenase
  4. Canniprene

Canniprene  (Synonyms: 大麻烯)

目录号: HY-N3535 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Canniprene 是大麻独有的异戊二烯化联苄基，是 5-脂氧合酶 (5-LO) 活性 (IC50=0.4 μM) 和环氧合酶/微粒体前列腺素 E2 合酶 (PGE2; IC50=10 μM) 的有效抑制剂。Canniprene 抑制炎性类花生酸的产生并影响前列腺素的生成。

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Canniprene Chemical Structure

Canniprene Chemical Structure

CAS No. : 70677-47-3

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规格 价格 是否有货 数量
1 mg ￥3510
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Canniprene 相关抗体

Top Publications Citing Use of Products

查看 Prostaglandin Receptor 亚型特异性产品:

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DP EP FP IP TXA2/TP TXB2

查看 Lipoxygenase 亚型特异性产品:

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5-LOX 12-LOX 15-LOX

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC50=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2; IC50=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins[1].

IC50 & Target[1]

5-LO

0.4 μM (IC50)

PGE2

10 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
10 μM
Compound: 1
Inhibition of mPGES-1 in interleukin-1 beta-stimulated human A549 cells microsomal membranes assessed as reduction in conversion of PGH2 to PGE2 pre-incubated for 15 mins followed by PGH2 substrate addition measured after 1 min by RP-HPLC method
Inhibition of mPGES-1 in interleukin-1 beta-stimulated human A549 cells microsomal membranes assessed as reduction in conversion of PGH2 to PGE2 pre-incubated for 15 mins followed by PGH2 substrate addition measured after 1 min by RP-HPLC method
[PMID: 28165233]
分子量

342.43

Formula

C21H26O4
CAS 号
性状

固体

颜色

White to off-white

中文名称

大麻烯
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Canniprene 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Canniprene70677-47-3大麻烯Prostaglandin ReceptorLipoxygenaseLOXCannabis sativainflammatory eicosanoidsprostaglandinspotentcyclooxygenase/microsomalInhibitorinhibitorinhibit

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