2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. COX Epoxide Hydrolase Lipoxygenase
  4. 5-LOX/sEH-IN-1

5-LOX/sEH-IN-1 (Compound 8o) 是具有心脏保护作用的双重 5-LOX/sEH 抑制剂，IC50 值分别为 3.05 μM 和 2.20 nM，也可以抑制 COX-2 的活性 (IC50=10.50 μM)。5-LOX/sEH-IN-1 具有镇痛和抗炎作用，同时降低了溃疡致病性，可以用于开发胃肠道和心血管副作用较小的抗炎剂。

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5-LOX/sEH-IN-1 Chemical Structure

5-LOX/sEH-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

5-LOX/sEH-IN-1 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC50 values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC50=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects[1].

IC50 & Target

IC50: 10.5 μM (COX-2)[1].
IC50: 2.20 nM (sEH)[1].
IC50: 3.05 μM (5-LOX)[1].
分子量

345.36

Formula

C18H15N7O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5-LOX/sEH-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-LOX/sEH-IN-1COXEpoxide HydrolaseLipoxygenaseCyclooxygenaseLOXcardioprotective effectsGastrointestinal protectiongastric ulceranti-inflammatory activityInhibitorinhibitorinhibit

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