1. Signaling Pathways
  2. Immunology/Inflammation
  3. COX
  4. COX Inhibitors

COX Inhibitors

COX

COX-1

COX-2

COX-3

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COX Inhibitors, Activators & Modulators
Product Name COX COX-1 COX-2 COX-3 Purity
Acetaminophen  
COX-1, IC50: 113.7 μM
COX-2, IC50: 25.8 μM
  99.98%
Indomethacin  
Human COX-1, IC50: 18 nM (in CHO cells)
Human COX-2, IC50: 26 nM (in CHO cells)
  99.91%
EIPA    
COX-2
  99.73%
Celecoxib  
COX-1, IC50: 15 μM
COX-2, IC50: 40 nM
  99.09%
Aspirin  
COX-1, IC50: 27.75 μM
COX-2, IC50: 1.17 mM
  99.82%
Oxidopamine hydrobromide    
COX-2
  99.95%
Oxidopamine hydrochloride    
COX-2
  99.91%
Gallic acid    
COX-2
  99.98%
Diclofenac  
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
  99.92%
Ibuprofen  
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
  99.97%
Catechin  
COX-1, IC50: 1.4 μM
    99.57%
20(S)-Ginsenoside Rg3    
COX-2
  99.94%
(-)-Epicatechin  
COX-1, IC50: 3.2 μM
    99.00%
Meloxicam  
COX-1, IC50: 36.6 μM
COX-2, IC50: 0.49 μM
  99.70%
Naproxen  
COX-1, IC50: 9.55 μM
COX-2, IC50: 5.65 μM
  99.98%
Diclofenac Sodium  
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
  99.94%
NS-398    
COX-2, IC50: 3.8 μM
  99.72%
Carprofen  
COX-1, IC50: 22.3 μM
COX-2, IC50: 3.9 μM
  99.76%
Xanthohumol  
COX-1
COX-2
  99.97%
Salicylic acid    
COX-2
  98.42%
Rebamipide    
COX-2
  99.94%
(-)-Epicatechin gallate  
COX-1, IC50: 7.5 μM
    98.57%
Phenacetin      
COX-3, IC50: 102 μM
99.94%
EIPA hydrochloride    
COX-2
  98.31%
(S)-(+)-Ibuprofen  
COX-1, IC50: 2.1 μM
COX-2, IC50: 1.6 μM
  99.98%
Ketoprofen  
COX-1, IC50: 2 nM (in human blood monocytes)
COX-2, IC50: 26 nM (in human blood monocytes)
  99.95%
Iguratimod    
COX-2, IC50: 20 μM
  99.93%
Piroxicam  
COX-1, IC50: 47 μM (in human monocytes)
COX-2, IC50: 25 μM (in human monocytes)
  99.71%
SC-560  
COX-1, IC50: 9 nM
COX-2, IC50: 6.3 μM
  99.79%
Psoralidin    
COX-2
  99.90%
Parecoxib    
COX-2
  99.29%
Ginsenoside Rd    
COX-2
  99.88%
Isoorientin    
COX-2, IC50: 39 μM
  99.26%
Ginsenoside C-K    
COX-2
  99.92%
Aspirin (Standard)  
COX-1
COX-2
  99.85%
Sodium Salicylate    
COX-2
  99.93%
Neochlorogenic acid    
COX-2
  99.77%
Prim-O-glucosylcimifugin    
COX-2
  99.94%
Mefenamic acid  
hCOX-1, IC50: 40 nM
hCOX-2, IC50: 3 μM
  99.95%
Rutaecarpine  
COX-1, IC50: 8.7 μM (in BMMC)
COX-2, IC50: 0.28 μM (in BMMC)
  99.00%
Niflumic acid    
COX-2, IC50: 100 nM
  99.88%
Diflunisal
COX
      99.93%
Ginsenoside Rg5    
COX-2
  99.87%
Guaiacol    
COX-2
  99.41%
Gamma-Mangostin    
COX-2
  99.91%
Salicin
COX
      99.77%
Nimesulide    
COX-2, IC50: 0.07-70 μM
  99.90%
Flurbiprofen
COX
COX-1
COX-2
  99.98%
Paradol    
COX-2
  99.42%
Harpagoside  
COX-1
COX-2
  99.41%
Fenofibric acid    
COX-2, IC50: 48 μM
  99.94%
Rofecoxib    
Human COX-2, IC50: 18 nM (in Chinese hamster ovary cells)
Human COX-2, IC50: 26 nM (in human osteosarcoma cells)
  99.84%
Etoricoxib  
COX-1, IC50: 116 μM (in human whole blood)
COX-2, IC50: 1.1 μM (in human whole blood)
  99.90%
Isofraxidin    
COX-2
  99.00%
Broussonin E    
COX-2
  98.18%
Valdecoxib  
COX-1, IC50: 140 μM
COX-2, IC50: 5 nM
  99.90%
Avicularin    
COX-2
  99.80%
Indobufen
COX
      99.98%
Cafestol    
COX-2
  99.91%
Madecassic acid    
COX-2
  99.23%
Roburic acid  
COX-1, IC50: 5 μM
COX-2, IC50: 9 μM
  ≥98.0%
Ibuprofen sodium  
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
  99.98%
[10]-Shogaol    
COX-2, IC50: 7.5 μM
  99.88%
Lumiracoxib  
COX-1, Ki: 3 μM
COX-2, Ki: 0.06 μM
  99.65%
Tolfenamic Acid    
COX-2, IC50: 13.49 μM (in cell)
  99.94%
cis-5-Dodecenoic acid  
COX-1
COX-2
  99.76%
Licofelone
COX, IC50: 0.21 μM
      ≥99.0%
γ-Tocopherol
Cyclooxygenase
      99.63%
Bromfenac sodium  
COX-1, IC50: 5.56 nM
COX-2, IC50: 7.45 nM
  98.52%
Ethyl Caffeate    
COX-2
  98.89%
Pectolinarigenin    
COX-2
  99.59%
SC-236  
COX-1, IC50: 17.8 μM
COX-2, IC50: 10 nM
  99.56%
Imrecoxib  
Human COX-1, IC50: 115 nM
Human COX-2, IC50: 18 nM
  99.48%
(S)-Flurbiprofen  
COX-1, IC50: 0.48 μM
COX-2, IC50: 0.47 μM
  99.89%
Lornoxicam  
COX-1, IC50: 5 nM (in cells)
COX-2, IC50: 45 nM (in cells)
  99.36%
[8]-Shogaol    
COX-2, IC50: 17.5 μM
  99.93%
Ketorolac  
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
  99.93%
Naproxen sodium  
COX-1, IC50: 9.55 μM (in intact cells )
COX-2, IC50: 5.65 μM (in intact cells )
  99.87%
Ampiroxicam
COX
      98.43%
Jaceosidin    
COX-2
  99.51%
S-(+)-Ketoprofen  
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
  99.88%
α-Humulene    
COX-2
  98.53%
Nabumetone    
COX-2
  99.90%
NF-κB/MAPK-IN-1    
COX-2
  98.42%
Etodolac  
COX-1, IC50: ∼50000 nM (in CHO cells)
COX-2, IC50: 41 nM (in CHO cells)
  99.77%
Syringaldehyde    
COX-2, IC50: 19.2 μM
  99.96%
Ginsenoside Rb3    
COX-2
  99.12%
Inulicin    
COX-2
  99.91%
FK 3311    
COX-2
  98.04%
Fenoprofen Calcium hydrate
COX
      99.69%
Ufenamate    
COX-2
  99.89%
3,3'-Diiodo-L-thyronine
COX
     
α-Spinasterol  
COX-1, IC50: 16.17 μM
COX-2, IC50: 7.76 μM
  99.15%
Oxaprozin  
COX-1, IC50: 2.2 μM
COX-2, IC50: 36 μM
  99.95%
Parecoxib Sodium    
COX-2
  99.94%
Ketorolac tromethamine salt  
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
  99.91%
Deracoxib    
COX-2
  99.65%
Gnetol  
COX-1, IC50: 0.78 μM
    99.86%
Hexahydrocurcumin    
COX-2
  99.88%
Pranoprofen  
COX-1
COX-2
  98.65%
Loxoprofen sodium  
COX-1, IC50: 6.5 μM
COX-2, IC50: 13.5 μM
  99.98%
N-tert-Butyl-α-phenylnitrone    
COX-2
  99.94%
(-)-Catechin gallate  
COX-1
COX-2
  99.98%
S-(+)-Marmesin    
COX-2
  99.04%
(E)-Ethyl p-methoxycinnamate  
COX-1, IC50: 1.12 μM
COX-2, IC50: 0.83 μM
  99.53%
AG-024322  
COX-1, Ki: 2.3 nM
COX-2, Ki: 3 nM
  98.53%
Nepafenac  
COX-1, IC50: 64.3 μM
    99.51%
Zaltoprofen  
COX-1, IC50: 1.3 μM
COX-2, IC50: 0.34 μM
  99.28%
Tenidap  
COX-1, IC50: 0.03 μM
COX-2, IC50: 1.2 μM
  99.32%
Salicylic acid-d6    
COX-2
  99.83%
Fenbufen  
COX-1, IC50: 3.9 μM
COX-2, IC50: 8.1 μM
  99.33%
Felbinac  
COX-1, IC50: 865.68 nM
COX-2, IC50: 976 nM
  99.74%
Eicosatetraynoic acid
COX, ID50: 8 μM
      ≥99.0%
Tolmetin  
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
  99.82%
Macelignan    
COX-2
  99.95%
Aceclofenac  
COX-1, IC50: 7.3 μM
COX-2, IC50: 3 μM
  99.91%
PTUPB  
COX-1, IC50: 100 μM
COX-2, IC50: 1.26 μM
  98.69%
Loxoprofen  
COX-1, IC50: 6.5 μM (in human whole blood)
COX-2, IC50: 13.5 μM (in human whole blood)
  99.80%
Humulone    
COX-2
  99.46%
Gallic acid hydrate    
COX-2
  99.81%
Byakangelicol    
COX-2
  99.87%
Moracin C    
COX-2
  99.54%
Asaraldehyde    
COX-2
  99.83%
Acemetacin  
COX-1, IC50: 85 μM (in human intact cell)
    99.97%
Tenoxicam  
COX-1
COX-2
  99.93%
Flunixin meglumine  
COX-1, IC50: 0.55 μM
COX-2, IC50: 3.24 μM
  99.71%
Adelmidrol    
COX-2
  ≥98.0%
CAY10404  
COX-1, IC50: >500 μM
COX-2, IC50: 1 nM
  99.69%
7,3',4'-Tri-O-methylluteolin    
COX-2
  99.28%
β-Elemonic acid    
COX-2
  99.90%
DuP-697  
hCOX-1, IC50: 800 nM
hCOX-2, IC50: 10 nM
  99.67%
(+)-Catechin hydrate  
COX-1, IC50: 1.4 μM
    99.59%
TFAP  
COX-1, IC50: 0.8 μM
    99.98%
Ampyrone
COX
      99.72%
Firocoxib  
COX-1, IC50: 7.5 μM
COX-2, IC50: 0.13 μM
  99.92%
Diclofenac potassium  
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 nM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 nM
  99.99%
Flurbiprofen axetil
COX
      99.85%
FR122047  
COX-1, IC50: 28 nM
    99.55%
Ketorolac-d5  
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
  98.31%
Bromfenac sodium hydrate  
COX-1, IC50: 5.56 nM
COX-2, IC50: 7.45 nM
  99.94%
Alminoprofen    
COX-2
  99.91%
SC-58125  
hCOX-1, IC50: >100 μM
hCOX-2, IC50: 0.04 μM
  99.92%
Sphondin    
COX-2
  99.70%
2,5-Di-tert-butylhydroquinone    
COX-2, IC50: 14.1 μM
  99.90%
Phenidone
COX
      99.00%
α-​Chaconine    
COX-2
  99.04%
Valeryl salicylate  
COX-1
    ≥99.0%
Phenyl β-D-glucopyranoside    
COX-2
  99.85%
Diclofenac diethylamine  
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
  99.96%
Polmacoxib    
COX-2, IC50: 0.1 μg/mL
  99.70%
β-Amyrone    
COX-2
  99.87%
BW 755C  
COX-1, IC50: 0.65 μg/mL
COX-2, IC50: 1.2 μg/mL
 
Teriflunomide impurity 3  
COX-1, IC50: 30 μM
    99.75%
Enflicoxib    
COX-2
  99.90%
Columbin  
COX-1, EC50: 327 μM
COX-2, EC50: 53.1 μM
  99.86%
Phenacetin (Standard)      
COX-3
99.97%
Fenofibric acid (Standard)    
COX-2
  99.16%
Isoxicam  
COX-1
COX-2
  99.83%
Propyphenazone
COX
      99.85%
Tolmetin sodium dihydrate  
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
  99.94%
Nitroflurbiprofen
COX
      99.64%
RWJ 63556    
COX-2
  99.35%
Vedaprofen  
COX-1
    99.81%
Tebufelone    
COX-2
  99.52%
Madecassic acid (Standard)    
COX-2
 
Plantanone B  
Ovine COX-1, IC50: 21.78±0.2 μM
Ovine COX-2, IC50: 44.01±0.42 μM
  99.16%
Otenaproxesul  
COX-1
COX-2
  98.03%
Nitroaspirin  
COX-1
   
Pamicogrel
Cyclooxygenase
      99.44%
Hamaudol  
COX-1, IC50: 0.3 mM
COX-2, IC50: 0.57 mM
  99.59%
Anemarsaponin B    
COX-2
 
Mofezolac  
COX-1, IC50: 1.44 nM
COX-2, IC50: 447 nM
  99.34%
Peonidin chloride    
COX-2
  98.70%
Pelubiprofen    
COX-2
  99.27%
GW-406381    
COX-2
  99.69%
Phenethyl ferulate
COX, IC50: 4.35 μM
      99.88%
Mavacoxib    
COX-2
  99.04%
Cimicoxib    
COX-2
  98.02%
3,9-Dihydroeucomin    
COX-2
 
Indomethacin-d4  
Human COX-1, IC50: 18 nM (in CHO cells)
Human COX-2, IC50: 26 nM (in CHO cells)
  99.78%
Acetaminophen (Standard)  
COX-1
COX-2
  99.94%
Hydrangenol    
COX-2
  99.33%
SC57666    
COX-2, IC50: 26 nM
  98.94%
Ketoprofen (lysinate)  
COX-1, IC50: 2 nM
COX-2, IC50: 26 nM
 
COX-2-IN-6    
COX-2
  98.80%
Aspirin lithium  
COX-1
COX-2
 
Indomethacin sodium  
COX-1, IC50: 18 nM
COX-2, IC50: 26 nM
 
COX-2/5-LOX-IN-3  
COX-1, IC50: 45.73 μM
COX-2, IC50: 5.45 μM
 
(±)-Aiphanol  
COX-1, IC50: 1.9 μM
COX-2, IC50: 9.9 μM
 
COX-2-IN-30  
COX-1, IC50: 10.4 μM
COX-2, IC50: 49 nM
 
PYZ18    
COX-2, IC50: 7.07 μM
 
MCI    
COX-2, IC50: 1.23 μM
 
Akt/NF-κB/MAPK-IN-1    
COX-2
 
Anti-inflammatory agent 20    
COX-2
 
VI-60    
COX-2
 
L 748780  
COX-1, IC50: > 100 μM
COX-2, IC50: 0.5 μM
 
COX-2-IN-27  
COX-1, IC50: 13.22 μM
COX-2, IC50: 0.045 μM
 
iNOS/COX-2-IN-1    
COX-2
 
COX-2-IN-26  
COX-1, IC50: 10.61 μM
COX-2, IC50: 0.067 μM
 
Eltenac  
COX-1, IC50: 0.03 μM
COX-2, IC50: 0.03 μM
 
Cudraflavone B  
COX-1
COX-2
 
COX-1-IN-2  
COX-1, IC50: 38.76 nM
   
Heterophdoid A    
COX-2
 
COX-2-IN-21  
COX-1, IC50: 12.4 μM
COX-2, IC50: 0.039 μM
 
COX-2-IN-19  
COX-1, IC50: 117.8 μM
COX-2, IC50: 1.76 μM
 
(-)-Epicatechin (Standard)  
COX-1
   
Antitumor agent-77    
COX-2
 
Avicularin (Standard)    
COX-2
 
Oxaprozin potassium  
COX-1, IC50: 2.2 μM
COX-2, IC50: 36 μM
 
Mefenamic acid-d4  
hCOX-1, IC50: 40 nM
hCOX-2, IC50: 3 nM
  ≥98.0%
COX-1/2-IN-3  
COX-1
COX-2
 
Antitumor agent-78    
COX-2
 
COX-2-IN-17  
COX-1, IC50: >10 μM
COX-2, IC50: 0.02 μM
 
(-)-Epicatechin gallate (Standard)  
COX-1
   
LM-4108  
Ovine COX-1, IC50: >66 μM
Human COX-2, IC50: 60 nM
 
COX-2-IN-44  
COX-1, IC50: 1.14 μM
COX-2, IC50: 0.18 μM
 
COX-1/2-IN-8  
COX-1, IC50: 2.14 ± 0.0 μM
COX-2, IC50: 0.58 ± 0.0 μM
 
Meloxicam sodium  
COX-1, IC50: 36.6 μM
COX-2, IC50: 0.49 μM
 
Balanophonin    
COX-2
 
COX-2-IN-23  
COX-1, IC50: 20.14 μM
COX-2, IC50: 0.28 μM
 
WYZ90  
COX-1, IC50: 5734 nM
COX-2, IC50: 75 nM
 
COX-2-IN-43  
COX-1, IC50: 0.983 μM
COX-2, IC50: 0.247 μM
 
Floctafenine  
COX-1
COX-2
 
Pifoxime  
COX-1
COX-2
 
Longiferone B    
COX-2
 
COX-2/sEH-IN-1  
COX-1, IC50: 8.72 μM
COX-2, IC50: 1.24 μM
 
COX-2-IN-14    
COX-2
 
COX-2-IN-24    
COX-2, IC50: 0.17 μM
 
Tolmetin sodium  
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
 
COX-2-IN-49    
COX-2, IC50: 2.671 μM
 
COX-2-IN-22    
COX-2, IC50: 8.6 μM
 
Indazole-Cl    
COX-2
  98.72%
(S)-(+)-Ibuprofen-d3  
COX-1, IC50: 2.1 μM
COX-2, IC50: 1.6 μM
  98.87%
COX-2-IN-47    
COX-2, IC50: 0.03 μM
 
COX-2/NLRP3-IN-1    
COX-2, IC50: 1.53 μM
 
COX-1/2-IN-2  
COX-1, IC50: 9.7±0.09 μM
COX-2, IC50: 4.6±1.45 μM
 
COX-2-IN-34    
COX-2, IC50: 0.42 μM
 
Anti-inflammatory agent 56    
COX-2
 
Taraxerol acetate  
COX-1, IC50: 116.3 μM
COX-2, IC50: 94.7 μM
 
Jaceosidin (Standard)    
COX-2
 
COX-2/PI3K-IN-2    
COX-2, Ki: 3.02 nM
 
COX-2-IN-32    
COX-2
 
COX-2-IN-16    
COX-2, IC50: 102 μM
 
ARN14494    
COX-2
 
COX-2-IN-42    
COX-2
 
COX-2-IN-20  
COX-1, IC50: 19.3 μM
COX-2, IC50: 17.9 nM
 
COX-2-IN-48    
Human COX-2, IC50: 51.7 nM
 
COX-2/PI3K-IN-1    
COX-2, Ki: 3.24 nM
 
COX-2-IN-40    
COX-2, IC50: 14.86 μM
 
Akt/NF-κB/JNK-IN-1    
COX-2
 
COX-2-IN-35    
COX-2, IC50: 4.37 nM
 
COX-2-IN-31  
COX-1, IC50: 12.5 μM
COX-2, IC50: 60 nM
 
Clematomandshurica saponin B    
COX-2
 
COX-2-IN-10    
COX-2
 
Ginsenoside Rb3 (Standard)    
COX-2
 
Daturaolone  
COX-1
   
Kadsulignan N    
COX-2
 
Flunixin  
COX-1, IC50: 0.55 μM
COX-2, IC50: 3.24 μM
 
COX-2-IN-5    
COX-2, IC50: 0.65 μM
 
Anti-inflammatory agent 78  
COX-1
COX-2
 
Shizukaol B    
COX-2
 
Lucidone    
COX-2
 
Topo I/COX-2-IN-2    
COX-2, IC50: 2.31 μM
 
COX-1/2-IN-1  
COX-1, IC50: 9.7±0.09 μM
COX-2, IC50: 4.6±1.45 μM
 
Nimesulide-d5    
COX-2, IC50: 0.07-70 μM
 
COX-2/LOX-IN-1    
COX-2, IC50: 0.55 μM
 
Bromfenac  
Human COX-1, IC50: 5.56 nM
Human COX-2, IC50: 7.45 nM
 
COX-2-IN-46    
COX-2, IC50: 87.74 nM
 
TX-1123  
COX-1, IC50: 15.7 μM
COX-2, IC50: 1.16 nM
 
Axinelline A  
COX-1, IC50: 8.89 μM
COX-2, IC50: 2.22 μM
 
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone  
COX-1
COX-2
  99.64%
Salicylic acid (Standard)    
COX-2
 
COX-2-IN-28  
COX-1, IC50: 13.21 μM
COX-2, IC50: 0.054 μM
 
Desmethyl Celecoxib    
COX-2, IC50: 32 nM
  99.42%
COX-2-IN-29  
COX-1, IC50: > 10 μM
COX-2, IC50: 0.005 μM
 
Loxoprofen sodium (dihydrate)  
COX-1, IC50: 6.5 μM (in human whole blood)
COX-2, IC50: 13.5 μM (in human whole blood)
 
COX-2/15-LOX-IN-1  
COX-1, IC50: 10.65 μM
COX-2, IC50: 0.075 μM
 
COX-1-IN-1  
COX-1, IC50: 0.23 μM
COX-2, IC50: 50 μM
 
Ermanin    
COX-2
 
Catechin hydrate  
COX-1, IC50: 1.4 μM
   
Fenoprofen Calcium
COX
     
ZLJ-6  
COX-1, IC50: 0.73 μM
COX-2, IC50: 0.31 μM
 
BF389  
COX-1, IC50: 4 μg/mL
COX-2, IC50: 8 μg/mL
 
Tenidap sodium  
COX-1
COX-2
 
NCX 466  
COX-1
COX-2
 
LY 178002
Cyclooxygenase
     
Flosulide    
COX-2
 
Thioflosulide    
COX-2, IC50: 2.3 nM
 
S-2474  
COX-1, IC50: 27 μM
COX-2, IC50: 11 nM
 
LFS-1107    
COX-2
 
COX-1/2-IN-9  
COX-1, IC50: 0.031 μM
COX-2, IC50: 0.010 μM
 
COX-2-IN-1    
COX-2, IC50: 3.9 μM
 
Timegadine
COX, IC50: 5 nM (in rabbit platelets)
COX, IC50: 20 μM (in rat brain)
     
Tilmacoxib    
Human COX-2, IC50: 85 nM
  ≥99.0%
COX/5-LO-IN-1
COX
     
COX-2-IN-2    
COX-2, IC50: 240 nM
  99.53%