2. Immunology/Inflammation
  3. COX
  4. Floctafenine

Floctafenine  (Synonyms: 夫洛非宁)

目录号: HY-A0259
产品使用指南 技术支持

Floctafenine 是非甾体抗炎药 (NSAID)，可用于缓解疼痛的研究。Floctafenine 是 COX-I 和 COX-2 活性的抑制剂，对 COX-I 的活性略高。Floctafenine 用于短期疼痛研究的研究。

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Floctafenine Chemical Structure

Floctafenine Chemical Structure

CAS No. : 23779-99-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1650
询价
5 mg ￥1500
7 - 9 周
10 mg ￥2500
7 - 9 周
25 mg ￥5000
7 - 9 周
50 mg 现货 7 - 9 周
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

Floctafenine 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Floctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent[1][2]. Floctafenine is an inhibitor of COX-1 and COX-2 activities in vitro,showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain research[3].

IC50 & Target[1]

COX-1

 

COX-2

 

体外研究
(In Vitro)

Floctafenine (0.1-100 μM; in the presence of LPS; 24 hours) is slightly more potent 1.5-fold to inhibit in vitro platelet COX-I than monocyte COX-2. The IC50 values for platelet COX-I and monocyte COX-2 inhibition are 2.33 μM (95%CI) and 3.47 μM (95%CI), respectively in heparinized whole blood samples[3].
Floctafenine (0.1-100 μM; in the presence of A23187; 1 hour) does not significantly affect A23187-caused LTB4 generation even up to 100 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Floctafenine 相关抗体:
体内研究
(In Vivo)

Floctafenine (intraperitoneal injection; 50 mg/kg; single dose; 30 minutes prior to p-benzoquinone) has an inhibitory effects on p-benoquinone-induced writhing in rats, inhibition of writhing is 65.98%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

406.36

Formula

C20H17F3N2O4
CAS 号
中文名称

弗洛非宁；夫洛非宁
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (246.09 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4609 mL 12.3044 mL 24.6087 mL
5 mM 0.4922 mL 2.4609 mL 4.9217 mL
查看完整储备液配制表

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Floctafenine 相关分类

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4609 mL 12.3044 mL 24.6087 mL 61.5218 mL
5 mM 0.4922 mL 2.4609 mL 4.9217 mL 12.3044 mL
10 mM 0.2461 mL 1.2304 mL 2.4609 mL 6.1522 mL
15 mM 0.1641 mL 0.8203 mL 1.6406 mL 4.1015 mL
20 mM 0.1230 mL 0.6152 mL 1.2304 mL 3.0761 mL
25 mM 0.0984 mL 0.4922 mL 0.9843 mL 2.4609 mL
30 mM 0.0820 mL 0.4101 mL 0.8203 mL 2.0507 mL
40 mM 0.0615 mL 0.3076 mL 0.6152 mL 1.5380 mL
50 mM 0.0492 mL 0.2461 mL 0.4922 mL 1.2304 mL
60 mM 0.0410 mL 0.2051 mL 0.4101 mL 1.0254 mL
80 mM 0.0308 mL 0.1538 mL 0.3076 mL 0.7690 mL
100 mM 0.0246 mL 0.1230 mL 0.2461 mL 0.6152 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Floctafenine23779-99-9弗洛非宁夫洛非宁COXCyclooxygenasenonsteroidal anti-inflammatory agentNSAIDanti-inflammatoryacute inflammationpaw edemapostoperative painosteoarthriticulcerogenicInhibitorinhibitorinhibit

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