2. Immunology/Inflammation
  3. COX
  4. COX-1/2-IN-3

COX-1/2-IN-3 (Compound 7a) 是一种 COX-1 和 COX-2 抑制剂。COX-2-IN-15 具有抗炎活性和低毒性。

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COX-1/2-IN-3 Chemical Structure

COX-1/2-IN-3 Chemical Structure

CAS No. : 2428387-82-8

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COX-1/2-IN-3 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

COX-1/2-IN-3 (Compound 7a) is a COX-1 and COX-2 inhibitor. COX-2-IN-15 shows anti-inflammatory activity with low toxicity[1].

IC50 & Target

COX-1

 

COX-2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
J774.A1 CC50
387.67 μM
Compound: 7a
Cytotoxicity against mouse J774A1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against mouse J774A1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32503692]
L929 CC50
439.39 μM
Compound: 7a
Cytotoxicity against mouse L929 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against mouse L929 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32503692]
体内研究
(In Vivo)

COX-1/2-IN-3 (Compound 7a) (1.25 and 0.625 mg/ear) exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

332.22

Formula

C14H8N2O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

COX-1/2-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-1/2-IN-32428387-82-8COXCyclooxygenaseanti-inflammatorylow toxicitymyeloperoxidaseear edemaInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-147693
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