2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species COX
  4. MCI

MCI 通过靶向清除活性氧 (ROS) 及下调环氧合酶-2 (COX-2COX-2 的 IC50 值为 1.23 μM. MCI 在胶原诱导的关节炎 (CIA) 模型中具有显著的抗炎作用。MCI 可用于类风湿性关节炎 (RA) 的研究。

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MCI Chemical Structure

MCI Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

MCI 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MCI alleviates inflammation by macrophage reprogramming via targeting ROS scavenging and COX-2 downregulation. MCI inhibits COX-2 with an IC50 value of 1.23 μM. MCI has significant anti-inflammatory effects in collagen-induced arthritis (CIA) models. MCI can be used in research for rheumatoid arthritis (RA)[1].

IC50 & Target[1]

COX-2

1.23 μM (IC50)

体外研究
(In Vitro)

MCI (8 μM， 2 h) 在 LPS 刺激的 RAW 264.7 细胞中抑制 ROS 的产生和 COX-2 的表达，进而诱导巨噬细胞从 M1 型转向 M2 型[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MCI 相关抗体:

Immunofluorescence[1]

Cell Line: LPS-stimulated RAW 264.7 cell
Concentration: 8 μM
Incubation Time: 2 h
Result: Inhibited the level of NF-κB p65 in the nuclei.
Increased the level of CD163.

Western Blot Analysis[1]

Cell Line: LPS-stimulated RAW 264.7 cell
Concentration: 8 μM
Incubation Time: 2 h
Result: Inhibited COX-2 and iNOS expression.
Increased arginase-1 (Arg-1) expression.
体内研究
(In Vivo)

MCI (1.05 mg/kg， 关节内注射， 每三天一次， 持续 18 天) 可预防 RA 的进展，并具有显著的抗炎作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Collagen-induced arthritis (CIA) models with BALB/c mice[1]
Dosage: 1.05 mg/kg, once every three days for 18 days
Administration: Intraarticularly injection
Result: Reduced the average ankle thickness and clinical index.
Reduced cartilage damage and essentially intact like that of healthy mice.
Clinical Trial
分子量

934.39

Formula

C45H52ClN7O13
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MCI 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCIReactive Oxygen SpeciesCOXCyclooxygenaseRAW 264.7macrophageM1M2collagen-induced arthritis (CIA) modelsrheumatoid arthritis (RA)Inhibitorinhibitorinhibit

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