2. 诱导疾病模型产品 Immunology/Inflammation Anti-infection
  3. 免疫与炎症疾病模型 消化系统疾病模型 COX Antibiotic Influenza Virus Bacterial
  4. 胃肠炎症及溃疡模型 胃肠道疾病模型
  5. 胃溃疡模型
  6. Indomethacin sodium

Indomethacin sodium  (Synonyms: 吲哚美辛钠; Indometacin sodium)

目录号: HY-15034
产品使用指南

摩尔计算器

Indomethacin (Indometacin) sodium 是一种口服有效的 COX1/2 抑制剂，COX-1 和 COX-2 的IC50 值分别为 18 nM 和 26 nM。Indomethacin sodium 具有抗癌和抗感染活性。Indomethacin sodium 可用于癌症、炎症和病毒感染的研究。

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Indomethacin sodium Chemical Structure

Indomethacin sodium Chemical Structure

CAS No. : 7681-54-1

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Indomethacin sodium 的其他形式现货产品:

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Other Forms of Indomethacin sodium:

Indomethacin sodium 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Indomethacin (Indometacin) sodium is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium has anticancer activity and anti-infective activity. Indomethacin sodium can be used for cancer, inflammation and viral infection research.[1][2][3].

IC50 & Targetsup>[1]

COX-1

18 nM (IC50)

COX-2

26 nM (IC50)

体外研究
(In Vitro)

Indomethacin (Indometacin) sodium (0-150 μM; 24 hours; 3LL-D122 cells) has anticancer activity in vitro[2].
Indomethacin (Indometacin) sodium (0-1000 μM) protects the host cells from damage caused by the virus through activates PKR, resulting in elF2α phosphorylation, and in turn shutting of translation of viral protein and inhibiting replication of the virus (IC50=2μM)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Indomethacin sodium 相关抗体:

Cell Viability Assay[2]

Cell Line: 3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells)
Concentration: 0, 20, 50, 100 and 150μM
Incubation Time: 24 hours
Result: Inhibited cell viability at 20 mM, with 50% inhibition at 60 nM.

Cell Cycle Analysis[2]

Cell Line: 3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells)
Concentration: 0, 30 and 80μM
Incubation Time: 24 hours
Result: Decreased in the percentage of cells at the G2/M phase and increased in the percentage of cells at G1 phase.
体内研究
(In Vivo)

Indomethacin (Indometacin) sodium (0.01-10 mg/kg; p.o.; for 3 hours; male Sprague-Dawley rats) induces paw oedema and hyperalgesmeasurement dose-dependently reversed carrageenan-induced hyperalgesia[1].
Indomethacin (Indometacin) sodium (10 mg/mL; p.o.; daily, for 29 days; male C57BL/6J mice) inhibits tumor growth in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.01-10 mg/kg
Administration: Oral administration; for 3 hours
Result: Inhibited the carrageenan-induced rat paw oedema (ED50=2.0 mg/kg) and hyperalgesia (ED50=1.5 mg/kg) in a dose-dependent manner.
Animal Model: Male C57BL/6J mice[2]
Dosage: 10 mg/mL
Administration: Oral administration; daily, for 29 days
Result: Delayed the onset of tumor growth and the initial growth rate of the footpad tumors.
Clinical Trial
分子量

379.77

Formula

C19H15ClNNaO4
CAS 号
中文名称

吲哚美辛钠
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Indomethacin sodium 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indomethacin7681-54-1Indometacin吲哚美辛钠COXAntibioticInfluenza VirusBacterialCyclooxygenaseanti-infectiveanticancerinflammationCOX-1COX-2Inhibitorinhibitorinhibit

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