2. Immunology/Inflammation
  3. COX
  4. COX-2-IN-27

COX-2-IN-27 是一种有效的选择性 COX-2 抑制剂，对 COX-1, COX-2, 15-LOX 的 IC50 值分别为 13.22, 0.045, 1.67 µM。COX-2-IN-27 具有抗炎活性。

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COX-2-IN-27 Chemical Structure

COX-2-IN-27 Chemical Structure

CAS No. : 2413565-17-8

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COX-2-IN-27 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC50 values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity[1].

IC50 & Target[1]

COX-1

13.22 μM (IC50)

COX-2

0.045 μM (IC50)

15-LOX

1.67 μM (IC50)

体外研究
(In Vitro)

COX-2-IN-27 (compound 15b) shows significant COX-2 selectivity with an SI value of 293.78[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

COX-2-IN-27 相关抗体:
体内研究
(In Vivo)

COX-2-IN-27 (28 µM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 93.20% and 109.08% in 4h and 3h, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

602.20

Formula

C29H24ClN7S3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

COX-2-IN-27 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-272413565-17-8COXCyclooxygenaseanti-inflammatoryedema inhibitorindomethacinInhibitorinhibitorinhibit

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产品名称：
COX-2-IN-27
目录号：
HY-150551
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