2. Immunology/Inflammation Anti-infection
  3. COX Interleukin Related Bacterial Fungal Parasite
  4. Lupeol acetate

Lupeol acetate  (Synonyms: 乙酸羽扇醇酯)

目录号: HY-126114 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Lupeol acetate 是 Lupeol 的衍生物。Lupeol acetate 是具有口服活性的抗炎、抗菌、抗锥虫和抗癌剂。Lupeol acetate 通过下调炎症细胞因子的表达和破骨细胞的生成，显著改善类风湿性关节炎的症状。Lupeol acetate 会抑制雄性大鼠的精子发生，最终导致大鼠不育。

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Lupeol acetate Chemical Structure

Lupeol acetate Chemical Structure

CAS No. : 1617-68-1

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1 mg ￥500
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5 mg ￥1400
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10 mg ￥2250
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Customer Review

Lupeol acetate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility[1][2][3][4].

IC50 & Target

COX-2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
29.826 μM
Compound: Compound 9
Cytotoxicity against human A549 cells assessed as cell growth inhibition by MTT assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition by MTT assay
[PMID: 27913179]
B16 IC50
22.7 μM
Compound: 3
Growth inhibition of mouse B16 2F2 cells after 3 days
Growth inhibition of mouse B16 2F2 cells after 3 days
[PMID: 12027734]
B16 ED50
7.5 μM
Compound: 3
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
[PMID: 12027734]
Hep 3B2 IC50
18.692 μM
Compound: Compound 9
Cytotoxicity against human Hep3B cells assessed as cell growth inhibition by MTT assay
Cytotoxicity against human Hep3B cells assessed as cell growth inhibition by MTT assay
[PMID: 27913179]
J774.A1 IC50
33.2 μM
Compound: 5
Antiinflammatory activity in mouse J774A1 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method
Antiinflammatory activity in mouse J774A1 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method
[PMID: 24909081]
RAW264.7 IC50
> 0.4 μM
Compound: lupenyl acetate
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs
[PMID: 20192236]
RAW264.7 IC50
36.7 μM
Compound: 5
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method
[PMID: 24909081]
体外研究
(In Vitro)

Lupeol acetate (3.125-100mg/mL；7 天) 能抑制 M. phaseolina 的生长，抑菌率为 79-81%[1]。
Lupeol acetate (3-94 µg/mL；24-48 小时) 诱导锥鞭毛体死亡的 EC50 为 15.82 µg/mL，抑制无鞭毛体阶段的 IC50 为 32.5 µg/mL[2]。
Lupeol acetate (0-80 μM；25 小时) 在 LPS (HY-D1056) 处理的 RAW 264.7 和 BMDMs 细胞中抑制 TNF-α 和 IL-1β 的激活和表达[3]。
Lupeol acetate (0-80 μM；25 小时) 通过下调 COX-2 和 MCP-1 的表达来降低巨噬细胞的迁移能力以及可以阻断 RANKL 介导的破骨细胞分化[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lupeol acetate 相关抗体:

Western Blot Analysis[3]

Cell Line: LPS(HY-D1056) treated RAW 264.7 cells
Concentration: 0, 10, 20, 40 and 80 μM
Incubation Time: 25 h
Result: Reduced the levels of COX-2 and MCP-1.
体内研究
(In Vivo)

Lupeol acetate (50 mg/kg；腹腔注射；21天) 在类风湿性关节炎小鼠模型中具有改善作用[3]。
Lupeol acetate (10 mg/day；口服；60 天) 在雄性大鼠中发挥抗生育的作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DBA/1J mouse aged 8 weeks old with collagen-induced arthritis[3]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection (i.p.); 21 days
Result: Reduced the incidence of arthritis and relieved symptoms of rheumatoid arthritis.
Significantly decreased clinical score and paw thickness.
Significantly lowered TNF-α and IL-1β levels in serum.
Inhibited inflammatory activity, significantly decreased the accumulation of 18F-FDG in the joints.
Reduced the infiltration of macrophages and bone erosion.
Animal Model: Male albino rats of the Wistar strain aged 3.5-4 months old (170 and 200 g)[4]
Dosage: 10 mg/day
Administration: Oral administration (p.o.); 60 days
Result: Did not cause any significant change in the body weights, but significantly reduced in the weight of reproductive organs, i.e. testes, epididymides, seminal vesicle and ventral prostate.
Significantly declined testicular sperm count, epididymal sperm count and motility, which resulted in reduction of male fertility by 100%.
Interfered with spermatogenesis and significantly reduced most tubule cell types.
Significantly reduced biochemical parameters of tissues i.e. protein, sialic acid, glycogen and cholesterol content of testes and seminal vesicular fructose.
分子量

468.75

Formula

C32H52O2
CAS 号
性状

固体

颜色

White to off-white

中文名称

乙酸羽扇醇酯
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

Ethanol 中的溶解度 : ≥ 2 mg/mL (4.27 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1333 mL 10.6667 mL 21.3333 mL
5 mM --- --- ---
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (291 KB) HNMR (270 KB) MS (198 KB)

产品使用指南 (1538 KB)
参考文献

Lupeol acetate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.1333 mL 10.6667 mL 21.3333 mL 53.3333 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lupeol1617-68-1乙酸羽扇醇酯COXInterleukin RelatedBacterialFungalParasiteCyclooxygenaseILmacrophagescytokinesarthritisantibacterial agentanti-trypanosomic agentanti-tumor agentInhibitorinhibitorinhibit

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