2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 疾病相关化合物库
  6. 非酒精性脂肪肝病化合物库
非酒精性脂肪肝病化合物库 - Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cat. No.: HY-L199

非酒精性脂肪性肝病 (NAFLD) 是世界范围内最常见的肝脏疾病之一，是代谢综合征的主要肝脏表现，非酒精性脂肪性肝病的增长与肥胖的流行是同步的。非酒精性脂肪肝由肝脏中过多的脂质积聚引起脂肪毒性，并表现出多种组织病理学异常。非酒精性脂肪性肝病可能会从单纯性脂肪病变发展为伴有或不伴有纤维化的非酒精性脂肪性肝炎 (NASH)，最终发展成肝硬化和肝细胞癌。但是到目前为止，已被批准上市的专门用于治疗 NAFLD 的药物非常少，因此加大力度开发此类药物是十分有必要的。

MCE 收录了 3,445 个具有明确或潜在抗非酒精性脂肪肝病活性的小分子化合物，是研究 NAFLD 病理机制及进行药物开发的重要工具。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 非酒精性脂肪肝病化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，3,363 个产品以 10 mM 浓度提供，69 个产品以 2 mM 浓度提供，13 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 3,445 compounds with definite or potential non-alcoholic fatty liver disease (NAFLD) activity for high throughput screening (HTS) and high content screening (HCS).

•   The compound library targets include Sirtuin, PPAR, NF-κB etc.

•   A useful tool for the discovery of compounds for NAFLD.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 3,445 NAFLD-related compounds supplied as pre-dissolved solutions or solid.
Solution: 3,363 compounds supplied in 10 mM solution, 69 compounds supplied in 2 mM solution, 13 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

NF-κB (329)

Akt (164)

PPAR (137)

Caspase (106)

PKC (92)

AMPK (90)

PI3K (77)

COX (71)

CCR (67)

CXCR (63)

HIV (61)

STAT (60)

ERK (59)

CDK (55)

HDAC (51)

mTOR (46)

JAK (41)

EGFR (38)

GCGR (36)

VEGFR (35)

FLT3 (34)

MMP (32)

PARP (32)

FXR (31)

HSP (31)

JNK (30)

Wnt (24)

Src (22)

GLUT (21)

PDGFR (21)

PKA (20)

HSV (19)

Ras (19)

FAK (18)

c-Kit (17)

MEK (17)

FGFR (15)

IAP (15)

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  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
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联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
    目录号：
    HY-L199
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