Chloroquine (Synonyms: 氯喹)

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Chloroquine 是一种广泛用于疟疾和类风湿性关节炎的抗炎试剂。Chloroquine 是自噬 (autophagy) 和 Toll 样受体 (TLRs) 的抑制剂。Chloroquine 有效抑制 SARS-CoV-2 (COVID-19) 感染 (EC₅₀=1.13 μM)。

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Chloroquine Chemical Structure

CAS No. : 54-05-7

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥550	In-stock
50 mg	￥350	In-stock
100 mg	￥500	In-stock
200 mg	￥875	In-stock
500 mg	￥1750	In-stock
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Other Forms of Chloroquine:

MCE 顾客使用本产品发表的 668 篇科研文献

Proliferation Assay

: Chloroquine purchased from MCE. Usage Cited in: Immun Inflamm Dis. 2023 Apr 12; 11:e830.; Chloroquine (10 μM; 30 min) reverses the effect of OmpA on autophagy by inhibiting the expression of Beclin1 and LC3II/I while increasing the expression of P62 in BMDCs.

: Chloroquine purchased from MCE. Usage Cited in: Immun Inflamm Dis. 2023 Apr 12; 11:e830.; Chloroquine (10 μM; 30 min) reverses the effect of OmpA on autophagy by inhibiting the expression of LC3 in BMDCs.

: Chloroquine purchased from MCE. Usage Cited in: Prostate. 2019 Jan;79(1):44-53. [Abstract]; Treatment with sub-dose of Everolimus (10 nM), together with CQ (5 µM) increases the levels of Bax and cleaved PARP, and decreases the levels of Bcl-2 expression in both PC3 and LNPER cells.

: Chloroquine purchased from MCE. Usage Cited in: Oncogene. 2018 May;37(22):2936-2952. [Abstract]; IPZ-treated U87 and U251 cells are treated with or without Baf-A1 (5 nM), CQ (40 μM), or MG132 (1 μM) for 48 h, followed by western blots.

: Chloroquine purchased from MCE. Usage Cited in: Biomed Pharmacother. 2018 Dec;109:1617-1627. [Abstract]; GFP-LC3B-expressing LX-2 cells are treated with DMSO, 3-MA (10 mM), or Chloroquine (30 μM) alone or in the presence of Carvedilol (CVD, 10 μM) for 24 h. The conversion of LC3B-I to LC3B-II is evaluated using immunoblotting.

: Chloroquine purchased from MCE. Usage Cited in: Int J Mol Med. 2018 May;41(5):2535-2544. [Abstract]; MC3T3-E1 cells are treated with AICAR (10 μM) in the presence or absence of 3-MA (5 mM) or CQ (10 μM) for 24 h, after which western blot analysis is conducted.

: Chloroquine purchased from MCE. Usage Cited in: Sci Rep. 2018 Mar 7;8(1):4108. [Abstract]; L02 cells exposed to PA (200 μM) with different concentrations of Rapamycin (Rapa) or Chloroquine (CQ) for 24 h. Palmitate (PA) induced higher protein expression of LC3 II/I and p62 compared with control as indicated by western blot.

: Chloroquine purchased from MCE. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2018 Feb 1;50(2):144-155. [Abstract]; Raw264.7 macrophages treated without or with Rapamycin (1 μΜ) or Chloroquine (20 μΜ) for 48 h. Western blot shows the protein expression levels of Atg5, Beclin1, LC3, and p62/SQSMT1.

: Chloroquine purchased from MCE. Usage Cited in: J Pharmacol Exp Ther. 2018 Oct;367(1):20-27. [Abstract]; Protein expression of LC3B and p62 in Panc-1 cells treated with Carboxamidotriazole (CAI) and/or Chloroquine (CQ).

: Chloroquine purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 5;503(2):501-507. [Abstract]; Western blot analysis of autophagy markers and LAMP2 in mice with AAV-vaspin and Chloroquine (CQ) pretreatment after I/R (1d).

: Chloroquine purchased from MCE. Usage Cited in: Neurosci Lett. 2018 Aug 24;682:112-117. [Abstract]; After treatment of CDDP with or without the autophagy inhibitor CQ, the expression of LC3-II in the CQ+CDDP group is less than that in the CQ group but is higher than that in the CDDP group at 24 h and 96 h.

: Chloroquine purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2018;48(6):2318-2336. [Abstract]; Cells are treated with Rapamycin (Rp; 10 μM)+Eicosapentaenoic acid (EPA; 40 μM) with or without Chloroquine (CQ; 5 μM) for 48 h. Cell extracts are prepared and subjected to western blot analysis.

: Chloroquine purchased from MCE. Usage Cited in: EBioMedicine. 2017 May;19:49-59. [Abstract]; mCherry-GFPLC3 puncta analysis in SPC-A-1 cells. Cells are transfected with mCherry-GFP-LC3 plasmid and incubated for 6 h. Next, cells are pretreated with or without Chloroquine (50 μM) for 1 h followed by stimulation of 5 μM Flu for 24 h or 36 h. Scale bar, 10 μm and 2 μm (magnified graph). The lysosomal inhibitor Chloroquine (CQ) raises the lysosomal pH and increases the autophagic flux.

: Chloroquine purchased from MCE. Usage Cited in: Sci Rep. 2017 Jun 7;7(1):2929. [Abstract]; p53 and Cell apoptosis. MCF7 and MDA-MB-231 cells are treated with 80 μM ω-3 FFAs, 20 μM ATRA alone or in combination for 48 h. The expression of PARP and p53 protein. β-Actin is used as an internal control.

: Chloroquine purchased from MCE. Usage Cited in: Oncotarget. 2017 Nov 22;8(65):109135-109150. [Abstract]; Cells are treated with RA (20 μM) plus ω-3 PUFAs (80 μM) with or without CQ (5 μM) for 24 h. Cell extracts are prepared and subjected to western blotting analysis.

: Chloroquine purchased from MCE. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2016 Dec;48(12):1075-1084. [Abstract]; The change of LC3 is analyzed by western blotting after 6 h hypoxia in the presence or absence of Chloroquine of WDR26-overexpressing H9c2 cells.

: Chloroquine purchased from MCE. Usage Cited in: Tumour Biol. 2016 Jul;37(7):8811-24. [Abstract]; Assays for autophagy activity. Immunoblot analysis for LC3B. Compared with the Lenti-NC cells, the Lenti-CD44v6 cells display a higher intensity of autophagy flux but not steady-state levels when treated with 5-FU (*P<0.001).

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生物活性
纯度 & 产品资料
参考文献

生物活性

Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM)^[1]^[2]^[3]^[4].

IC₅₀ & Target^[1]^[2][3]^[5]

Plasmodium

Malaria

TLRs

SARS-COV-2

HIV-1

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
184B5	IC₅₀	63.08 μM Compound: Chloroquine	Antiproliferative activity against human 184B5 cells after 72 hrs by SRB assay Antiproliferative activity against human 184B5 cells after 72 hrs by SRB assay	[PMID: 26602827]
184B5	IC₅₀	76.13 μM Compound: CQ	Cytotoxicity against human 184B5 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human 184B5 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 28586716]
184B5	GI₅₀	76.13 μM Compound: Chloroquine	Cytotoxicity against human 184B5 cells after 48 hrs by SRB assay Cytotoxicity against human 184B5 cells after 48 hrs by SRB assay	[PMID: 20106668]
184B5	GI₅₀	76.13 μM Compound: CQ	Cytotoxicity against human 184B5 cells after 48 hrs by SRB assay Cytotoxicity against human 184B5 cells after 48 hrs by SRB assay	[PMID: 19804979]
A-431	ED₅₀	> 20 μg/mL Compound: chloroquine	Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
A549	IC₅₀	100 μM Compound: Chloroquine	Anticancer activity against human A549 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay Anticancer activity against human A549 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay	[PMID: 34303874]
BEAS-2B	IC₅₀	3.07 μM Compound: Chloroquine	Anticancer activity against human BEAS-2B cells assessed as cell growth inhibition measured for 72 hrs by MTT assay Anticancer activity against human BEAS-2B cells assessed as cell growth inhibition measured for 72 hrs by MTT assay	[PMID: 34303874]
BHK-21	CC₅₀	> 20 μM Compound: 1; CQ	cytotoxicity against golden hamster BHK-21 cells incubated for 72 hrs by MTT assay cytotoxicity against golden hamster BHK-21 cells incubated for 72 hrs by MTT assay	[PMID: 32845145]
BT-474	IC₅₀	> 1000 μM Compound: 29; CQ	Cytotoxicity against human BT474 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human BT474 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29211480]
BT-483	GI₅₀	10.2 μM Compound: CQ	Growth inhibition of human BT-483 cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium Growth inhibition of human BT-483 cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium	[PMID: 19748786]
BXPC-3	IC₅₀	25 μM Compound: CQ, Lys01	Antiproliferative activity against human BxPC3 cells after 72 hrs by SRB method Antiproliferative activity against human BxPC3 cells after 72 hrs by SRB method	[PMID: 25699157]
Caco-2	GI₅₀	38.67 μM Compound: CQ, 1	Antiproliferative activity against human Caco2 cells after 2 days by sulforhodamine B assay Antiproliferative activity against human Caco2 cells after 2 days by sulforhodamine B assay	[PMID: 24184076]
CCRF-CEM	IC₅₀	23 μM Compound: 1, CQ	Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation by Coulter counter analysis Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation by Coulter counter analysis	[PMID: 26114811]
CHO	CC₅₀	155 μM Compound: Chloroquine	Cytotoxicity against CHO cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against CHO cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 25791675]
CHO	IC₅₀	35.8 μM Compound: CQ	Cytotoxicity against CHO cells by MTT assay Cytotoxicity against CHO cells by MTT assay	[PMID: 26832222]
CHO	IC₅₀	57.84 μM Compound: CQ	Cytotoxicity against CHO cells by MTT assay Cytotoxicity against CHO cells by MTT assay	[PMID: 29559277]
Erythrocyte	CC₅₀	> 100 μg/mL Compound: Chloroquine	Hemolytic activity in human erythrocytes measured after 1 hr by microtiter plate method Hemolytic activity in human erythrocytes measured after 1 hr by microtiter plate method	[PMID: 27667552]
FM3A	EC₅₀	32000 nM Compound: 1	Cytotoxicity against mouse FM3A cells assessed as inhibition of increase in cell density after 48 hrs Cytotoxicity against mouse FM3A cells assessed as inhibition of increase in cell density after 48 hrs	[PMID: 18479926]
HCA1	IC₅₀	> 10 μM Compound: CQ	Cytotoxicity against mouse HCA1 cells assessed as cell viability by MTT assay Cytotoxicity against mouse HCA1 cells assessed as cell viability by MTT assay	[PMID: 34558909]
HCC827	IC₅₀	76 μM Compound: CQ, Lys01	Antiproliferative activity against human HCC827 cells after 72 hrs by SRB method Antiproliferative activity against human HCC827 cells after 72 hrs by SRB method	[PMID: 25699157]
HCT-116	IC₅₀	33.7 μM Compound: 70	Cytotoxicity against human HCT116 cells after 72 hrs by WST1 assay Cytotoxicity against human HCT116 cells after 72 hrs by WST1 assay	[PMID: 12398531]
HCT-8	IC₅₀	27 nM Compound: chloroquine	Antimicrobial activity against Cryptosporidium parvum infected in human HCT-8 cells after 48 hrs by ELISA Antimicrobial activity against Cryptosporidium parvum infected in human HCT-8 cells after 48 hrs by ELISA	[PMID: 18591280]
HEK293	IC₅₀	> 10 μM Compound: Chloroquine	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue dye based fluorescence assay Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue dye based fluorescence assay	[PMID: 36799121]
HEK293	IC₅₀	> 1000 μM Compound: CQ	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 24 hrs by neutral red dye based analysis Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 24 hrs by neutral red dye based analysis	[PMID: 33666415]
HEK293	IC₅₀	> 120 nM Compound: Chloroquine	Cytotoxicity against HEK293 cells by alamar blue assay Cytotoxicity against HEK293 cells by alamar blue assay	[PMID: 27212070]
HEK293	IC₅₀	> 40 μM Compound: Chloroquine	Cytotoxicity against HEK293 cells incubated for 72 hrs by resazurin dye based assay Cytotoxicity against HEK293 cells incubated for 72 hrs by resazurin dye based assay	[PMID: 31961680]
HEK293	CC₅₀	≥ 20 μM Compound: Chloroquine	Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay	[PMID: 30537832]
HEK293	IC₅₀	0.49 μM Compound: Chloroquine	Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay	[PMID: 29236492]
HEK293	IC₅₀	101.19 μM Compound: Chloroquine	Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay	[PMID: 33744688]
HEK293	IC₅₀	12 μM Compound: chloroquine	Cytotoxicity against human HEK293 cells after 72 hrs by alamar blue assay Cytotoxicity against human HEK293 cells after 72 hrs by alamar blue assay	[PMID: 21155593]
HEK293	CC₅₀	20 μM Compound: Chloroquine	Cytotoxicity against human HEK293 cells assessed as cell viability measured for 24 hrs by MTT assay Cytotoxicity against human HEK293 cells assessed as cell viability measured for 24 hrs by MTT assay	[PMID: 34303874]
HEK293	IC₅₀	40 μM Compound: Chloroquine	Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by Alamar blue assay Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by Alamar blue assay	[PMID: 28774427]
HEK293	IC₅₀	48 μM Compound: Chloroquine	Cytotoxicity against HEK293 cells after 72 hrs by Alamar Blue assay Cytotoxicity against HEK293 cells after 72 hrs by Alamar Blue assay	[PMID: 21190857]
HEK-293T	IC₅₀	> 50 μM Compound: 1, CQ	Cytotoxicity against HEK293T cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against HEK293T cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 24077527]
HEL	CC₅₀	58.5 μM Compound: 1, CQ	Cytotoxicity against human HEL cells assessed as inhibition of cell viability by colorimetric formazan-based MTS assay Cytotoxicity against human HEL cells assessed as inhibition of cell viability by colorimetric formazan-based MTS assay	[PMID: 26114811]
HEL 299	CC₅₀	33.6 μM Compound: CQ	Cytotoxicity against HEL 299 cells assessed as reduction in cell viability measured after 1 to 2 hrs by MTS colorimetric assay Cytotoxicity against HEL 299 cells assessed as reduction in cell viability measured after 1 to 2 hrs by MTS colorimetric assay	[PMID: 35571875]
HeLa	IC₅₀	> 100 μM Compound: CQ	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 22858300]
HeLa	EC₅₀	> 100 μM Compound: 1, CQ	Antiviral activity against Vesicular stomatitis virus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect by visual scoring analysis Antiviral activity against Vesicular stomatitis virus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect by visual scoring analysis	[PMID: 26114811]
HeLa	EC₅₀	> 100 μM Compound: 1, CQ	Antiviral activity against Coxsackievirus B4 infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect by visual scoring analysis Antiviral activity against Coxsackievirus B4 infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect by visual scoring analysis	[PMID: 26114811]
HeLa	EC₅₀	> 100 μM Compound: 1, CQ	Antiviral activity against Respiratory syncytial virus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect by visual scoring analysis Antiviral activity against Respiratory syncytial virus infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect by visual scoring analysis	[PMID: 26114811]
HeLa	CC₅₀	> 1000 μg/mL Compound: CQ	Cytotoxic activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxic activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 25920564]
HeLa	IC₅₀	> 1000 μM Compound: CQ	Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs by neutral red dye based analysis Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs by neutral red dye based analysis	[PMID: 33666415]
HeLa	IC₅₀	12.48 μM Compound: CQ	Antiviral activity against VSV-G pseudotyped HIV1 lentiviral particles infected in human HeLa cells incubated for 48 hrs by spectrofluorometry Antiviral activity against VSV-G pseudotyped HIV1 lentiviral particles infected in human HeLa cells incubated for 48 hrs by spectrofluorometry	[PMID: 22858300]
HeLa	IC₅₀	18 μM Compound: 1, CQ	Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation by Coulter counter analysis Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation by Coulter counter analysis	[PMID: 26114811]
HeLa	GI₅₀	18.6 μM Compound: CQ	Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium	[PMID: 19748786]
HeLa	EC₅₀	19.6 μM Compound: Chloroquine	Inhibition of lysosomal acidification in human HeLa cells incubated for 3 hrs by LysoTracker Red DND-99 staining based array scan method Inhibition of lysosomal acidification in human HeLa cells incubated for 3 hrs by LysoTracker Red DND-99 staining based array scan method	[PMID: 32356659]
HeLa	GI₅₀	2.1 μM Compound: CQ	Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 100 uM ZnCl2 Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 100 uM ZnCl2	[PMID: 19748786]
HeLa	IC₅₀	29.96 μM Compound: Chloroquine	Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay	[PMID: 26602827]
HeLa	GI₅₀	4.4 μM Compound: CQ	Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM CuCl2 Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM CuCl2	[PMID: 19748786]
HeLa	GI₅₀	5.3 μM Compound: CQ	Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10 uM CuCl2 Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10 uM CuCl2	[PMID: 19748786]
HeLa	GI₅₀	5.6 μM Compound: CQ	Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM ZnCl2 Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM ZnCl2	[PMID: 19748786]
HeLa	GI₅₀	6.1 μM Compound: CQ	Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 1 uM CuCl2 Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 1 uM CuCl2	[PMID: 19748786]
HeLa	IC₅₀	9.665 μM Compound: CQ	Cytotoxicity against human HeLa cells assessed as cell survival after 7 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as cell survival after 7 hrs by MTT assay	[PMID: 17768052]
HeLa	IC₅₀	9.67 μM Compound: Chloroquine	Cytotoxicity against human HeLa cells after 7 days by MTT assay Cytotoxicity against human HeLa cells after 7 days by MTT assay	[PMID: 21489789]
Hep 3B2	IC₅₀	> 10 μM Compound: CQ	Cytotoxicity against human Hep3B cells assessed as cell viability by MTT assay Cytotoxicity against human Hep3B cells assessed as cell viability by MTT assay	[PMID: 34558909]
HepG2	IC₅₀	> 10 μM Compound: CQ	Cytotoxicity against human HepG2 cells assessed as cell viability by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability by MTT assay	[PMID: 34558909]
HepG2	IC₅₀	> 10 μM Compound: CQ	Cytotoxicity against human HepG2 cells after 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs	[PMID: 24904967]
HepG2	IC₅₀	> 10 μM Compound: CQ	Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells after 48 hrs Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells after 48 hrs	[PMID: 24904967]
HepG2	CC₅₀	> 1000 μg/mL Compound: CQ	Cytotoxic activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxic activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 25920564]
HepG2	EC₅₀	> 10000 nM Compound: 36	Antimicrobial activity against Plasmodium berghei sporozoites infected in 12 hrs compound pretreated human HepG2 cells assessed as reduction in viability of exoerythrocytic forms measured after 48 hrs of incubation by luciferase bioluminescence assay Antimicrobial activity against Plasmodium berghei sporozoites infected in 12 hrs compound pretreated human HepG2 cells assessed as reduction in viability of exoerythrocytic forms measured after 48 hrs of incubation by luciferase bioluminescence assay	[PMID: 24641010]
HepG2	CC₅₀	> 30 μM Compound: CQ	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay	[PMID: 33620219]
HepG2	CC₅₀	1.6 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells expressing CD81 assessed as cell viability after 72 hrs by CellTiter-glo assay Cytotoxicity against human HepG2 cells expressing CD81 assessed as cell viability after 72 hrs by CellTiter-glo assay	[PMID: 25791675]
HepG2	EC₅₀	10.1 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells after 48 hrs by CellTiter-Glo assay Cytotoxicity against human HepG2 cells after 48 hrs by CellTiter-Glo assay	[PMID: 29800827]
HepG2	EC₅₀	10430 nM Compound: CQ	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 32959656]
HepG2	IC₅₀	116 μM Compound: CHL, CLQ	Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay	[PMID: 22380766]
HepG2	IC₅₀	116 μM Compound: CQ	Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay	[PMID: 22321992]
HepG2	IC₅₀	12.9 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human HepG2 cells after 72 hrs by Alamar Blue assay	[PMID: 21190857]
HepG2	IC₅₀	12020 ng/mL Compound: CQ	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 25654185]
HepG2	CC₅₀	137.42 μM Compound: CQ	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30199706]
HepG2	IC₅₀	1650 nM Compound: Chloroquine	Antiplasmodial activity against liver stage of Plasmodium yoelii 17X NL sporozoites infected in human HepG2 cells expressing CD81 after 48 hrs by DAPI staining-based immunofluorescence analysis Antiplasmodial activity against liver stage of Plasmodium yoelii 17X NL sporozoites infected in human HepG2 cells expressing CD81 after 48 hrs by DAPI staining-based immunofluorescence analysis	[PMID: 25791675]
HepG2	GI₅₀	22.16 μM Compound: CQ	Cytotoxicity against human HepG2 cells after 48 hrs by lactate dehydrogenase assay Cytotoxicity against human HepG2 cells after 48 hrs by lactate dehydrogenase assay	[PMID: 21882831]
HepG2	EC₅₀	25 μM Compound: CQ	Cytotoxicity against human HepG2 cells assessed as intracellular ATP level after 72 hrs by Celltiter-Glo luminescent assay Cytotoxicity against human HepG2 cells assessed as intracellular ATP level after 72 hrs by Celltiter-Glo luminescent assay	[PMID: 21910466]
HepG2	IC₅₀	25 μM Compound: CQ, chloroquine	Cytotoxicity against human HepG2 cells assessed as reduction in cell number incubated for 72 hrs Cytotoxicity against human HepG2 cells assessed as reduction in cell number incubated for 72 hrs	[PMID: 26135471]
HepG2	CC₅₀	30 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 34364164]
HepG2	CC₅₀	30 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27654395]
HepG2	CC₅₀	30 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay	[PMID: 27155463]
HepG2	CC₅₀	30 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 25791675]
HepG2	CC₅₀	30 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 25282267]
HepG2	CC₅₀	30 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 24946216]
HepG2	CC₅₀	30 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 24858543]
HepG2	CC₅₀	30 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 22889559]
HepG2	CC₅₀	30 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 22608675]
HepG2	CC₅₀	30 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 21852132]
HepG2	CC₅₀	30 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 21741131]
HepG2	IC₅₀	30 μM Compound: chloroquine	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 19926173]
HepG2	IC₅₀	30 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 19482476]
HepG2	IC₅₀	30 μM Compound: chloroquine	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 17981462]
HepG2	IC₅₀	37577 nM Compound: CQ	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 34111350]
HepG2	IC₅₀	37577 nM Compound: CQ	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32390431]
HepG2	IC₅₀	37577 nM Compound: CQ	Cytotoxicity against human HepG2 cells measured after 24 to 36 hrs by resazurin dye based fluorescence assay Cytotoxicity against human HepG2 cells measured after 24 to 36 hrs by resazurin dye based fluorescence assay	[PMID: 30852885]
HepG2	EC₅₀	384 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 29879353]
HepG2	IC₅₀	384 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 33158577]
HepG2	CC₅₀	393 μM Compound: 4	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 29324340]
HepG2	GI₅₀	43.09 μM Compound: CQ	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 48 hrs by LDH assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 48 hrs by LDH assay	[PMID: 25684422]
HepG2	IC₅₀	49.02 μM Compound: Chloroquine	Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay	[PMID: 34303874]
HepG2	CC₅₀	504.1 μM Compound: Chloroquine	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 23353738]
HepG2	IC₅₀	73.7 μM Compound: CQ	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by neutral red dye based analysis Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by neutral red dye based analysis	[PMID: 33666415]
HepG2	IC₅₀	8.3 μM Compound: chloroquine	Cytotoxicity against human HepG2 cells after 72 hrs by alamar blue assay Cytotoxicity against human HepG2 cells after 72 hrs by alamar blue assay	[PMID: 21155593]
HepG2	CC₅₀	810 μM Compound: 1	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 24469080]
HFF-1	GI₅₀	> 100 μM Compound: CQ, 1	Antiproliferative activity against human HFF1 cells after 2 days by sulforhodamine B assay Antiproliferative activity against human HFF1 cells after 2 days by sulforhodamine B assay	[PMID: 24184076]
HL-60	IC₅₀	> 100 μM Compound: CQ	Cytotoxicity against human HL60 cells after 24 hrs by MTT assay Cytotoxicity against human HL60 cells after 24 hrs by MTT assay	[PMID: 29398445]
HL-60	GI₅₀	128 μM Compound: CQ	Cytotoxicity against human HL60 cells by alamar blue assay Cytotoxicity against human HL60 cells by alamar blue assay	[PMID: 23266185]
HMEC-1	IC₅₀	> 100 μM Compound: CQ	Antiproliferative activity against SV40 large T-antigen 38 immortalized HMEC1 cells after 72 hrs by MTT assay Antiproliferative activity against SV40 large T-antigen 38 immortalized HMEC1 cells after 72 hrs by MTT assay	[PMID: 28128956]
HMEC-1	IC₅₀	> 20 μM Compound: CQ	Cytotoxicity against HMEC1 assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against HMEC1 assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 26081764]
HMEC-1	CC₅₀	> 32000 nM Compound: CQ	Cytotoxicity against HMEC1 cells after 72 hrs by MTT assay Cytotoxicity against HMEC1 cells after 72 hrs by MTT assay	[PMID: 20797868]
HMEC-1	IC₅₀	> 32000 nM Compound: CQ	Cytotoxicity against HMEC1 cells by MTT assay Cytotoxicity against HMEC1 cells by MTT assay	[PMID: 18562202]
HMEC-1	IC₅₀	> 38 μM Compound: CQ	Cytotoxicity against HMEC1 cells after 72 hrs by MTT assay Cytotoxicity against HMEC1 cells after 72 hrs by MTT assay	[PMID: 25497962]
HMEC-1	CC₅₀	> 38 μM Compound: Chloroquine	Cytotoxicity against HMEC1 assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against HMEC1 assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25311562]
HMEC-1	IC₅₀	> 38000 nM Compound: CQ	Cytotoxicity against human HMEC1 cells after 72 hrs by MTT assay Cytotoxicity against human HMEC1 cells after 72 hrs by MTT assay	[PMID: 22917857]
HMEC-1	IC₅₀	> 38000 nM Compound: CQ	Cytotoxicity against human HMEC1 cells after 72 hrs by MTT assay Cytotoxicity against human HMEC1 cells after 72 hrs by MTT assay	[PMID: 22901673]
HMEC-1	IC₅₀	> 40 μM Compound: CQ	Cytotoxicity in human HMEC1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity in human HMEC1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 30996801]
HT-1080	ED₅₀	6.5 μg/mL Compound: chloroquine	Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
HT-29	IC₅₀	3.6 μM Compound: CQ, Lys01	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 25699157]
HT-29	IC₅₀	58000 ng/mL Compound: chloroquine	Cytotoxicity against human HT-29 cells after 72 hrs by Alamar blue assay Cytotoxicity against human HT-29 cells after 72 hrs by Alamar blue assay	[PMID: 9644053]
Huh-7	CC₅₀	> 100 μg/mL Compound: CQ	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36306538]
Huh-7	IC₅₀	> 15 μM Compound: CQ	Antiplasmodial activity against liver stage of Plasmodium berghei expressing GFP-Luc infected in HuH7 cells incubated at 1 hr prior to infection followed by compound replenisment at 24 hrs post-infection measured after 48 hrs by Alamar blue assay Antiplasmodial activity against liver stage of Plasmodium berghei expressing GFP-Luc infected in HuH7 cells incubated at 1 hr prior to infection followed by compound replenisment at 24 hrs post-infection measured after 48 hrs by Alamar blue assay	[PMID: 23290049]
Huh-7	CC₅₀	> 50 μM Compound: 1; CQ	Cytotoxicity against human Huh-7 cells incubated for 1 hr by MTS assay Cytotoxicity against human Huh-7 cells incubated for 1 hr by MTS assay	[PMID: 32845145]
Huh-7	IC₅₀	15.9 μM Compound: 1, CQ	Antiplasmodial activity against Plasmodium berghei liver stage form transfected in human Huh-7 cells assessed as cell viability after 48 hrs by luciferase reporter gene assay Antiplasmodial activity against Plasmodium berghei liver stage form transfected in human Huh-7 cells assessed as cell viability after 48 hrs by luciferase reporter gene assay	[PMID: 23273038]
J774	EC₅₀	47.2 μM Compound: CQ	Cytotoxicity against mouse J774 cells after 72 hrs by CellTiter-96 aqueous one solution cell proliferation assay Cytotoxicity against mouse J774 cells after 72 hrs by CellTiter-96 aqueous one solution cell proliferation assay	[PMID: 29215279]
J774.1	IC₅₀	18.4 μM Compound: Chloroquine	Cytotoxicity against mouse J774.1 cells after 24 hrs by AlamarBlue based cytotoxicity assay Cytotoxicity against mouse J774.1 cells after 24 hrs by AlamarBlue based cytotoxicity assay	[PMID: 27316542]
Jurkat	IC₅₀	95 μM Compound: CQ	Cytotoxicity against human Jurkat cells after 20 hrs by propidium iodide staining based flow cytometry Cytotoxicity against human Jurkat cells after 20 hrs by propidium iodide staining based flow cytometry	[PMID: 29398445]
Jurkat E6.1	IC₅₀	83.64 μM Compound: CQ	Cytotoxicity against human Jurkat E6-1 cells after 24 hrs by MTT assay Cytotoxicity against human Jurkat E6-1 cells after 24 hrs by MTT assay	[PMID: 29398445]
K562	CC₅₀	> 25000 nM Compound: CQ	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 20797868]
K562	IC₅₀	25.3 μM Compound: Chloroquine	Toxicity in human K562 cells assessed as effect on cell growth measured after 24 hrs by [3H]thymidine incorporation based assay Toxicity in human K562 cells assessed as effect on cell growth measured after 24 hrs by [3H]thymidine incorporation based assay	[PMID: 32687714]
K562	IC₅₀	29030 nM Compound: CQ	Cytotoxicity against human K562 cells by MTT assay Cytotoxicity against human K562 cells by MTT assay	[PMID: 18562202]
K562	IC₅₀	32 μM Compound: chloroquine	Cytotoxicity against human K562 cells after 72 hrs by flow cytometry Cytotoxicity against human K562 cells after 72 hrs by flow cytometry	[PMID: 19926173]
K562	IC₅₀	32 μM Compound: Chloroquine	Cytotoxicity against human K562 cells after 72 hrs by flow cytometry Cytotoxicity against human K562 cells after 72 hrs by flow cytometry	[PMID: 19482476]
K562	IC₅₀	43.8 μg/mL Compound: Chloroquine	Cytotoxicity against Homo sapiens (human) K562 cells by Sulphorhodamine B assay Cytotoxicity against Homo sapiens (human) K562 cells by Sulphorhodamine B assay	10.1007/s00044-011-9694-1
K562	CC₅₀	9.7 μM Compound: chloroquine	Cytotoxicity against human K562 cells assessed as radioactive thymidine incorporation after 24 hrs Cytotoxicity against human K562 cells assessed as radioactive thymidine incorporation after 24 hrs	[PMID: 18680278]
KB	IC₅₀	110 μM Compound: CQ	Cytotoxicity against human KB cells after 48 hrs by alamar blue assay Cytotoxicity against human KB cells after 48 hrs by alamar blue assay	[PMID: 18215443]
KB	ED₅₀	17.4 μg/mL Compound: chloroquine	Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
KB	ED₅₀	17.4 μg/mL Compound: chloroquine	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 11421741]
KB	IC₅₀	20.4 μM Compound: chloroquine	Cytotoxicity against human KB cells after 48 hrs by MTT assay Cytotoxicity against human KB cells after 48 hrs by MTT assay	[PMID: 11809075]
KB	IC₅₀	22.5 μM Compound: chloroquine	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 19879150]
KB	ED₅₀	30.8 μM Compound: chloroquine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 16562832]
KB	ED₅₀	33700 nM Compound: chloroquine	Cytotoxicity against human KB cells after 72 hrs by SRB assay Cytotoxicity against human KB cells after 72 hrs by SRB assay	[PMID: 9917283]
KB	IC₅₀	34 μM Compound: CQ	Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay	[PMID: 24900724]
KB	CC₅₀	44 μM Compound: Chloroquine	Cytotoxicity against human KB cells after 72 hrs by alamar blue assay Cytotoxicity against human KB cells after 72 hrs by alamar blue assay	[PMID: 20014857]
KB	IC₅₀	97725.5 nM Compound: Chloroquine	Cytotoxicity against human KB cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human KB cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24148834]
KB-V1	ED₅₀	7.8 μg/mL Compound: chloroquine	Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
L02	IC₅₀	15 μM Compound: Chloroquine	Anticancer activity against human L02 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay Anticancer activity against human L02 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay	[PMID: 34303874]
L1210	IC₅₀	15 μM Compound: 1, CQ	Cytotoxicity against mouse L1210 cells assessed as inhibition of cell proliferation by Coulter counter analysis Cytotoxicity against mouse L1210 cells assessed as inhibition of cell proliferation by Coulter counter analysis	[PMID: 26114811]
L6	IC₅₀	0.007 μg/mL Compound: chloroquine	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 24056020]
L6	IC₅₀	0.11 μg/mL Compound: Chloroquine	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in rat L6 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected in rat L6 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting	[PMID: 22352841]
L6	IC₅₀	0.178 μM Compound: Chloroquine	Antiparasitic activity against Plasmodium falciparum K1 infected in rat L6 cells assessed as inhibition of parasite growth preincubated for 48 hrs before [3H]hypoxanthine addition measured after 24 hrs by [3H]hypoxanthine incorporation assay Antiparasitic activity against Plasmodium falciparum K1 infected in rat L6 cells assessed as inhibition of parasite growth preincubated for 48 hrs before [3H]hypoxanthine addition measured after 24 hrs by [3H]hypoxanthine incorporation assay	[PMID: 21937228]
L6	IC₅₀	116.9 μM Compound: chl	Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay	[PMID: 33148495]
L6	IC₅₀	117 mM Compound: CQ	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23871911]
L6	IC₅₀	117 μM Compound: CQ	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 19928900]
L6	IC₅₀	117 μM Compound: CQ	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 19606902]
L6	IC₅₀	117 μM Compound: CQ	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 19267462]
L6	IC₅₀	188.5 nM Compound: Chloroquine	Cytotoxicity against rat L6 cells by alamar blue assay Cytotoxicity against rat L6 cells by alamar blue assay	[PMID: 17178177]
L6	IC₅₀	188.5 μM Compound: CQ	Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay	[PMID: 30962114]
L6	IC₅₀	188.5 μM Compound: CQ	Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay	[PMID: 27344215]
L6	IC₅₀	188.5 μM Compound: Ch	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 25746816]
L6	IC₅₀	188.5 μM Compound: Chl	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 19395265]
L6	IC₅₀	188.5 μM Compound: Chl	Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorometry Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorometry	[PMID: 23880082]
L6	IC₅₀	188.5 μM Compound: chloroquine (chl)	Cytotoxicity against rat L6 cells after 72 hrs by microplate alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by microplate alamar blue assay	[PMID: 18502136]
L6	IC₅₀	188.5 μM Compound: chl	Cytotoxicity against rat L6 cells after 72 hrs by microplate assay Cytotoxicity against rat L6 cells after 72 hrs by microplate assay	[PMID: 17544672]
L6	IC₅₀	76.5 μM Compound: Chloroquine	Cytotoxicity against rat L6 cells after 3 days by Alamar blue assay Cytotoxicity against rat L6 cells after 3 days by Alamar blue assay	[PMID: 24956553]
L6	IC₅₀	76.5 μM Compound: CQ	Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay	[PMID: 24268543]
L6	IC₅₀	76.5 μM Compound: CQ	Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay	[PMID: 23795673]
L6	IC₅₀	78 μM Compound: CQ	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 25195945]
L6	IC₅₀	90.92 μM Compound: CQ	Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by alamar blue assay	[PMID: 28031151]
L6	IC₅₀	90.92 μM Compound: CQ	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue staining based fluorometric assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue staining based fluorometric assay	[PMID: 28279559]
L6	IC₅₀	91 μM Compound: Chloroquine	Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by alamar blue assay	[PMID: 28284860]
L6	IC₅₀	91 μM Compound: Chloroquine	Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue based inverted microscopy analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue based inverted microscopy analysis	[PMID: 31784198]
L6	CC₅₀	92.8 μM Compound: CHQ	Cytotoxicity against rat L6 cels assessed as reduction in cell viability after 72 hrs by Alamar Blue dye-based fluorometric analysis Cytotoxicity against rat L6 cels assessed as reduction in cell viability after 72 hrs by Alamar Blue dye-based fluorometric analysis	[PMID: 30615444]
L929	IC₅₀	14 μg/mL Compound: Chloroquine	Cytotoxicity against mouse L929 cells after 5 days by MTT assay Cytotoxicity against mouse L929 cells after 5 days by MTT assay	[PMID: 18922036]
L929	EC₅₀	18.6 μg/mL Compound: chloroquine	Cytotoxicity against mouse L929 cells by MTT assay Cytotoxicity against mouse L929 cells by MTT assay	[PMID: 16854076]
LN-229	IC₅₀	3.6 μM Compound: CQ, Lys01	Cytotoxicity against human LN229 cells after 72 hrs by MTT assay Cytotoxicity against human LN229 cells after 72 hrs by MTT assay	[PMID: 25699157]
LNCaP	ED₅₀	14.3 μg/mL Compound: chloroquine	Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
LNCaP	IC₅₀	32.87 μM Compound: CQ, chloroquine	Cytotoxicity against human LNCAP cells assessed as reduction in cell number incubated for 72 hrs Cytotoxicity against human LNCAP cells assessed as reduction in cell number incubated for 72 hrs	[PMID: 26135471]
Lymphocyte	IC₅₀	> 100 μM Compound: CQ	Cytotoxicity against human lymphocytes after 24 to 48 hrs by MTT assay Cytotoxicity against human lymphocytes after 24 to 48 hrs by MTT assay	[PMID: 29398445]
Lymphocyte	IC₅₀	12000 nM Compound: Chloroquine	Cytotoxicity against C57B1/6J mouse splenic lymphocyte after 24 hrs by alamar blue assay Cytotoxicity against C57B1/6J mouse splenic lymphocyte after 24 hrs by alamar blue assay	[PMID: 20088608]
Mahlavu	IC₅₀	> 10 μM Compound: CQ	Cytotoxicity against human Mahlavu cells assessed as cell viability by MTT assay Cytotoxicity against human Mahlavu cells assessed as cell viability by MTT assay	[PMID: 34558909]
MCF-10A	GI₅₀	81.26 μM Compound: CQ	Antiproliferative activity against human MCF10A cells after 48 hrs by SRB assay Antiproliferative activity against human MCF10A cells after 48 hrs by SRB assay	[PMID: 20561720]
MCF-10A	GI₅₀	81.26 μM Compound: Chloroquine	Cytotoxicity against human MCF10A cells after 48 hrs by SRB assay Cytotoxicity against human MCF10A cells after 48 hrs by SRB assay	[PMID: 20106668]
MCF-10A	GI₅₀	81.26 μM Compound: CQ	Cytotoxicity against human MCF10A cells after 48 hrs by SRB assay Cytotoxicity against human MCF10A cells after 48 hrs by SRB assay	[PMID: 19804979]
MCF7	IC₅₀	> 100 μg/mL Compound: chloroquine	Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs	[PMID: 19296616]
MCF7	IC₅₀	13.2 μM Compound: 8	Antiproliferative activity against human MCF7 cells measured after 2 days by SRB assay Antiproliferative activity against human MCF7 cells measured after 2 days by SRB assay	[PMID: 35231830]
MCF7	CC₅₀	19.4 μM Compound: Chloroquine	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 20014857]
MCF7	CC₅₀	19.4 μM Compound: Chloroquine	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 48 hrs by XTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 48 hrs by XTT assay	[PMID: 24594524]
MCF7	CC₅₀	19.4 μM Compound: Chloroquine	Cytotoxicity against human MCF7 cells after 48 hrs by XTT reduction assay Cytotoxicity against human MCF7 cells after 48 hrs by XTT reduction assay	[PMID: 24686013]
MCF7	IC₅₀	23.43 μM Compound: CQ, chloroquine	Cytotoxicity against human MCF7 cells assessed as reduction in cell number incubated for 72 hrs Cytotoxicity against human MCF7 cells assessed as reduction in cell number incubated for 72 hrs	[PMID: 26135471]
MCF7	IC₅₀	36.1 μM Compound: CQ	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 19892554]
MCF7	IC₅₀	38.44 μM Compound: CQ	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 28586716]
MCF7	GI₅₀	38.44 μM Compound: CQ	Antiproliferative activity against human p53+/- MCF7 cells after 48 hrs by SRB assay Antiproliferative activity against human p53+/- MCF7 cells after 48 hrs by SRB assay	[PMID: 20561720]
MCF7	GI₅₀	38.44 μM Compound: Chloroquine	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 20106668]
MCF7	GI₅₀	38.44 μM Compound: CQ	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 19804979]
MCF7	GI₅₀	64.35 μM Compound: CQ, 1	Antiproliferative activity against human MCF7 cells after 2 days by sulforhodamine B assay Antiproliferative activity against human MCF7 cells after 2 days by sulforhodamine B assay	[PMID: 24184076]
MDA-MB-231	IC₅₀	22.52 μM Compound: CQ	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 28586716]
MDA-MB-231	GI₅₀	22.52 μM Compound: CQ	Antiproliferative activity against human p53, pRB mutant and estrogen receptor deficient MDA-MB-231 cells after 48 hrs by SRB assay Antiproliferative activity against human p53, pRB mutant and estrogen receptor deficient MDA-MB-231 cells after 48 hrs by SRB assay	[PMID: 20561720]
MDA-MB-231	GI₅₀	22.52 μM Compound: CQ	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay	[PMID: 19804979]
MDA-MB-231	IC₅₀	36.53 μM Compound: Chloroquine	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay	[PMID: 26602827]
MDA-MB-361	IC₅₀	97 μM Compound: CQ, chloroquine	Cytotoxicity against human MDA-MB-361 cells assessed as reduction in cell number incubated for 72 hrs Cytotoxicity against human MDA-MB-361 cells assessed as reduction in cell number incubated for 72 hrs	[PMID: 26135471]
MDA-MB-468	IC₅₀	10.6 μM Compound: CQ	Cytotoxicity against human MDA-MB-468 cells measured after 72 hrs by Celltiter-Glo assay Cytotoxicity against human MDA-MB-468 cells measured after 72 hrs by Celltiter-Glo assay	[PMID: 33200929]
MDA-MB-468	IC₅₀	19.86 μM Compound: Chloroquine	Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by SRB assay	[PMID: 26602827]
MDA-MB-468	IC₅₀	28.58 μM Compound: CQ	Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 28586716]
MDA-MB-468	GI₅₀	28.58 μM Compound: Chloroquine	Cytotoxicity against human MDA-MB-468 cells after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-468 cells after 48 hrs by SRB assay	[PMID: 20106668]
MDA-MB-468	GI₅₀	28.58 μM Compound: CQ	Cytotoxicity against human MDA-MB-468 cells after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-468 cells after 48 hrs by SRB assay	[PMID: 19804979]
MDCK	CC₅₀	55.6 μM Compound: 1, CQ	Cytotoxicity against MDCK cells assessed as inhibition of cell viability by colorimetric formazan-based MTS assay Cytotoxicity against MDCK cells assessed as inhibition of cell viability by colorimetric formazan-based MTS assay	[PMID: 26114811]
MIA PaCa-2	EC₅₀	14 μM Compound: Chloroquine	Antiproliferative activity against human MIA PaCa-2 cells assessed as cell viability measured after 72 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as cell viability measured after 72 hrs by MTT assay	[PMID: 28105281]
MKN-28	GI₅₀	44.44 μM Compound: CQ, 1	Antiproliferative activity against human MKN28 cells after 2 days by sulforhodamine B assay Antiproliferative activity against human MKN28 cells after 2 days by sulforhodamine B assay	[PMID: 24184076]
MRC5	CC₅₀	50 μM Compound: CQ	Cytotoxicity against human MRC5 cells after 7 days by MTT assay Cytotoxicity against human MRC5 cells after 7 days by MTT assay	[PMID: 18226428]
MRC5	CC₅₀	50 μM Compound: chloroquine(CQ)	Cytotoxic effect on human diploid embryonic lung cell line (MRC-5) using the colorimetric MTT assay Cytotoxic effect on human diploid embryonic lung cell line (MRC-5) using the colorimetric MTT assay	[PMID: 15357968]
MRC5	CC₅₀	50 μM Compound: Chloroquine	Cytotoxicity against human diploid embryonic lung cell line (MRC5 cells) using the colorimetric MTT assay Cytotoxicity against human diploid embryonic lung cell line (MRC5 cells) using the colorimetric MTT assay	[PMID: 14552779]
MRC5	IC₅₀	50 μM Compound: Chloroquine	Cytotoxicity tests were performed on a human diploid embryonic lung cell line (MRC5) using the colorimetric MTT assay Cytotoxicity tests were performed on a human diploid embryonic lung cell line (MRC5) using the colorimetric MTT assay	[PMID: 12182868]
MRC5	CC₅₀	50 μM Compound: CQ	Cytotoxicity against human diploid embryonic lung MRC5 cells by colorimetric MTT assay Cytotoxicity against human diploid embryonic lung MRC5 cells by colorimetric MTT assay	[PMID: 16263280]
MRC5	IC₅₀	50000 nM Compound: CQ	Cytotoxicity against human MRC5 cells after 5 days by MTT assay Cytotoxicity against human MRC5 cells after 5 days by MTT assay	[PMID: 18819813]
MRC5	IC₅₀	58.2 μM Compound: Chloroquine	Cytotoxicity against human MRC5 cells assessed as cell growth inhibition and measured after 2 days by WST-8 assay Cytotoxicity against human MRC5 cells assessed as cell growth inhibition and measured after 2 days by WST-8 assay	[PMID: 35512262]
MRC5	IC₅₀	64 nM Compound: CQ	Cytotoxicity against human MRC5 after 3 days Cytotoxicity against human MRC5 after 3 days	[PMID: 20329733]
NCH89	IC₅₀	41.2 μM Compound: CQ	Antiproliferative activity against human carmustine-resistant NCH-89 cells assessed as BrdU incorporation after 48 hrs Antiproliferative activity against human carmustine-resistant NCH-89 cells assessed as BrdU incorporation after 48 hrs	[PMID: 20329733]
NCI-H460	IC₅₀	52 μM Compound: CQ, Lys01	Antiproliferative activity against human H460 cells after 72 hrs by SRB method Antiproliferative activity against human H460 cells after 72 hrs by SRB method	[PMID: 25699157]
NFF	IC₅₀	> 1000 μM Compound: CQ	Cytotoxicity against human NFF cells after 3 days by SRB assay Cytotoxicity against human NFF cells after 3 days by SRB assay	[PMID: 24084158]
NFF	IC₅₀	34 μM Compound: Chloroquine	Cytotoxicity against human NFF assessed as growth inhibition after 3 days by sulforhodamine B assay Cytotoxicity against human NFF assessed as growth inhibition after 3 days by sulforhodamine B assay	[PMID: 22269277]
NFF	IC₅₀	37.3 μM Compound: Chloroquine	Cytotoxicity against human NFF cells after 3 days by sulforhodamine B assay Cytotoxicity against human NFF cells after 3 days by sulforhodamine B assay	[PMID: 23117170]
NFF	IC₅₀	45900 nM Compound: chloroquine	Cytotoxicity against human NFF after 72 hrs by SRB assay Cytotoxicity against human NFF after 72 hrs by SRB assay	[PMID: 24900794]
NIH3T3	IC₅₀	> 50 μM Compound: 1, CQ	Cytotoxicity against mouse NIH/3T3 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 24077527]
NIH3T3	IC₅₀	71954 nM Compound: CQ	Cytotoxicity against mouse 3T3 cells after 48 hrs by MTT assay Cytotoxicity against mouse 3T3 cells after 48 hrs by MTT assay	[PMID: 22055713]
NSC	CC₅₀	94.95 μM Compound: 38	Cytotoxicity against human NSC after 5 days by CellTiter Blue assay Cytotoxicity against human NSC after 5 days by CellTiter Blue assay	[PMID: 31549836]
P388	ED₅₀	> 5 μg/mL Compound: chloroquine	Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay	[PMID: 8450319]
PBMC	IC₅₀	5.1 μM Compound: chloroquine	Antiproliferative activity against PHA-stimulated human PBMC after 72 hrs by MTT assay Antiproliferative activity against PHA-stimulated human PBMC after 72 hrs by MTT assay	[PMID: 18222568]
Peritoneal macrophage cell	CC₅₀	88.6 μM Compound: CQ	Cytotoxicity against mouse peritoneal macrophages after 48 hrs by trypan blue exclusion method Cytotoxicity against mouse peritoneal macrophages after 48 hrs by trypan blue exclusion method	[PMID: 21724395]
SH-SY5Y	CC₅₀	30 μM Compound: CQ	Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 29559198]
SK-BR-3	IC₅₀	50.37 μM Compound: CQ, chloroquine	Cytotoxicity against human SKBR3 cells assessed as reduction in cell number incubated for 72 hrs Cytotoxicity against human SKBR3 cells assessed as reduction in cell number incubated for 72 hrs	[PMID: 26135471]
SK-MEL-2	ED₅₀	> 20 μg/mL Compound: chloroquine	Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
Splenocyte	IC₅₀	3.46 μM Compound: CQ	Cytotoxicity against concanavalin-stimulated BALB/c mouse splenocytes after 72 hrs by resazurin dye reduction method Cytotoxicity against concanavalin-stimulated BALB/c mouse splenocytes after 72 hrs by resazurin dye reduction method	[PMID: 19908867]
SW480	IC₅₀	14.7 μM Compound: 8	Antiproliferative activity against human SW480 cells measured after 3 days by SRB assay Antiproliferative activity against human SW480 cells measured after 3 days by SRB assay	[PMID: 35231830]
THP-1	IC₅₀	40 μM Compound: Chloroquine	Cytotoxicity against human THP1 cells assessed as cell viability after 72 hrs by Alamar blue assay Cytotoxicity against human THP1 cells assessed as cell viability after 72 hrs by Alamar blue assay	[PMID: 19914747]
THP-1	IC₅₀	40 μM Compound: Chloroquine	Cytotoxicity against human THP1 cells using propidium iodide staining after 72 hrs by flow cytometry Cytotoxicity against human THP1 cells using propidium iodide staining after 72 hrs by flow cytometry	[PMID: 20638854]
THP-1	IC₅₀	40 μM Compound: chloroquine	Cytotoxicity against human THP1 cells by MTT assay Cytotoxicity against human THP1 cells by MTT assay	[PMID: 17981462]
THP-1	IC₅₀	40 μM Compound: Chloroquine	Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide staining-based flow cytometry Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide staining-based flow cytometry	[PMID: 19748781]
Vero	CC₅₀	> 100 μM Compound: 4	Cytotoxicity against african green monkey Vero cells incubated for 3 days Cytotoxicity against african green monkey Vero cells incubated for 3 days	[PMID: 32539378]
Vero	IC₅₀	> 14.88 μM Compound: CQ	Cytotoxicity against African green monkey Vero cells after 48 hrs by neutral red uptake assay Cytotoxicity against African green monkey Vero cells after 48 hrs by neutral red uptake assay	[PMID: 27936446]
Vero	CC₅₀	> 150 μM Compound: Chloroquine	Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr	10.1101/2020.03.20.999730
Vero	CC₅₀	> 25 μM Compound: Chloroquine	Cytotoxicity against African green monkey Vero cells infected with SARS-CoV-2 betaCoV/KOR/KCDC03/2020 assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay Cytotoxicity against African green monkey Vero cells infected with SARS-CoV-2 betaCoV/KOR/KCDC03/2020 assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay	[PMID: 33160024]
Vero	CC₅₀	> 500 μM Compound: CQ	Cytotoxicity against African green monkey Vero cells measured after 72 hrs by resazurin assay Cytotoxicity against African green monkey Vero cells measured after 72 hrs by resazurin assay	[PMID: 30469040]
Vero	CC₅₀	> 500 μM Compound: Chloroquine	Cytotoxicity against African green monkey Vero cells after 3 days by resazurin dye based fluorescence assay Cytotoxicity against African green monkey Vero cells after 3 days by resazurin dye based fluorescence assay	[PMID: 29940466]
Vero	EC₅₀	10 μM Compound: chloroquine	Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay	[PMID: 24926807]
Vero	EC₅₀	10 μM Compound: chloroquine	Antiviral activity against chikungunya virus Indian ocean strain 899 infected in Vero cells assessed as virus-induced cytopathic effect after 6 to 7 days Antiviral activity against chikungunya virus Indian ocean strain 899 infected in Vero cells assessed as virus-induced cytopathic effect after 6 to 7 days	[PMID: 25970561]
Vero	EC₅₀	11 μM Compound: chloroquine	Antiviral activity against Sindbis virus HRsp infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay Antiviral activity against Sindbis virus HRsp infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay	[PMID: 24926807]
Vero	EC₅₀	11 μM Compound: Chloroquine	Antiviral activity against Sindbis virus HRsp infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay Antiviral activity against Sindbis virus HRsp infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay	[PMID: 23215460]
Vero	EC₅₀	11 μM Compound: Chloroquine	Antiviral activity against Chikungunya virus 899 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay Antiviral activity against Chikungunya virus 899 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay	[PMID: 23215460]
Vero	EC₅₀	11 μM Compound: chloroquine	Antiviral activity against Chikungunya virus Indian Ocean strain 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 7 days by MTS/PMS method Antiviral activity against Chikungunya virus Indian Ocean strain 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 7 days by MTS/PMS method	[PMID: 24800626]
Vero	EC₅₀	11 μM Compound: chloroquine	Antiviral activity against Chikungunya virus strain 899 infected in african green monkey Vero cells assessed as inhibition of virus induced cell death measured after 7 days Antiviral activity against Chikungunya virus strain 899 infected in african green monkey Vero cells assessed as inhibition of virus induced cell death measured after 7 days	[PMID: 25946116]
Vero	EC₅₀	11 μM Compound: chloroquine	Antiviral activity against Sindbis virus strain HRsp infected in african green monkey Vero cells assessed as inhibition of virus induced cell death measured after 7 days Antiviral activity against Sindbis virus strain HRsp infected in african green monkey Vero cells assessed as inhibition of virus induced cell death measured after 7 days	[PMID: 25946116]
Vero	IC₅₀	125 ng/mL Compound: Chloroquine	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method	[PMID: 19914074]
Vero	CC₅₀	125 μM Compound: Chloroquine	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 26338359]
Vero	CC₅₀	125.9 μM Compound: Chloroquine	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 23354072]
Vero	EC₅₀	13.8 μM Compound: chloroquine	Antiviral activity against Semliki forest virus Vietnam infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay Antiviral activity against Semliki forest virus Vietnam infected in African green monkey Vero cells assessed as inhibition of virus-induced cell death after 6 to 7 days by MTS assay	[PMID: 24926807]
Vero	EC₅₀	14 μM Compound: Chloroquine	Antiviral activity against Semliki forest virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay Antiviral activity against Semliki forest virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay	[PMID: 23215460]
Vero	EC₅₀	14 μM Compound: chloroquine	Antiviral activity against Semliki forest virus strain Vietnam infected in african green monkey Vero cells assessed as inhibition of virus induced cell death measured after 7 days Antiviral activity against Semliki forest virus strain Vietnam infected in african green monkey Vero cells assessed as inhibition of virus induced cell death measured after 7 days	[PMID: 25946116]
Vero	IC₅₀	17 ng/mL Compound: Chloroquine	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method	[PMID: 19914074]
Vero	IC₅₀	21 μM Compound: Chloroquine	Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTS assay Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 23727538]
Vero	CC₅₀	226 μM Compound: Chloroquine	Cytotoxicity against African green monkey Vero cells measured after 3 days by resazurin dye based fluorescence assay Cytotoxicity against African green monkey Vero cells measured after 3 days by resazurin dye based fluorescence assay	[PMID: 28319782]
Vero	IC₅₀	234.47 μM Compound: CQ	Cytotoxicity against African green monkey Vero cells by MTS assay Cytotoxicity against African green monkey Vero cells by MTS assay	[PMID: 26748697]
Vero	CC₅₀	235109 nM Compound: Chloroquine	Cytotoxicity against african green monkey Vero C1008 cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero C1008 cells after 72 hrs by MTT assay	[PMID: 23270565]
Vero	CC₅₀	412 μM Compound: Chloroquine	Cytotoxicity against African green monkey Vero cells after 72 hrs by XTT assay Cytotoxicity against African green monkey Vero cells after 72 hrs by XTT assay	[PMID: 28092859]
Vero	CC₅₀	412 μM Compound: Chloroquine	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by XTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by XTT assay	[PMID: 28068604]
Vero	IC₅₀	48.5 μg/mL Compound: Chloroquinec	Cytotoxicity against african green monkey Vero cells by MTT assay Cytotoxicity against african green monkey Vero cells by MTT assay	[PMID: 18855442]
Vero	IC₅₀	484 nM Compound: Chloroquine	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs	[PMID: 19833520]
Vero	IC₅₀	5.2 ng/mL Compound: CQ	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in African green monkey (Cercopithecus aethiops) Vero cells after 72 hrs by twofold serial dilution method Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in African green monkey (Cercopithecus aethiops) Vero cells after 72 hrs by twofold serial dilution method	[PMID: 19665899]
Vero	IC₅₀	50 nM Compound: Chloroquine	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs	[PMID: 19833520]
Vero	CC₅₀	684.68 μM Compound: 16, CQ	Cytotoxicity against african green monkey Vero cells after 2 days by resazurin assay Cytotoxicity against african green monkey Vero cells after 2 days by resazurin assay	[PMID: 25147607]
Vero	IC₅₀	7.28 μM Compound: Chloroquine	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr	10.1101/2020.03.20.999730
Vero	CC₅₀	75 μM Compound: Chloroquine	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 28763644]
Vero	CC₅₀	75000 ng/mL Compound: CQ	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 23182089]
Vero	CC₅₀	89 μM Compound: chloroquine	Cytotoxicity against African green monkey Vero cells assessed as inhibition of overall cell metabolism after 6 to 7 days by MTS assay Cytotoxicity against African green monkey Vero cells assessed as inhibition of overall cell metabolism after 6 to 7 days by MTS assay	[PMID: 24926807]
Vero	CC₅₀	89 μM Compound: chloroquine	Cytotoxicity against african green monkey Vero cells assessed as inhibition of cell metabolism after 72 hrs by MTS assay Cytotoxicity against african green monkey Vero cells assessed as inhibition of cell metabolism after 72 hrs by MTS assay	[PMID: 25946116]
Vero	CC₅₀	89 μM Compound: Chloroquine	Cytotoxicity against African green monkey Vero cells by MTS assay Cytotoxicity against African green monkey Vero cells by MTS assay	[PMID: 30681849]
Vero	CC₅₀	89 μM Compound: Chloroquine	Cytotoxicity against african green monkey Vero cells by MTS assay Cytotoxicity against african green monkey Vero cells by MTS assay	[PMID: 23215460]
Vero	CC₅₀	89 μM Compound: Chloroquine	Cytotoxicity against African green monkey Vero cells assessed as decrease in cell viability after 5 days by MTS/PMS method Cytotoxicity against African green monkey Vero cells assessed as decrease in cell viability after 5 days by MTS/PMS method	[PMID: 29336951]
Vero	CC₅₀	89 μM Compound: chloroquine	Cytotoxicity against non-infected African green monkey Vero cells after 7 days by MTS/PMS method Cytotoxicity against non-infected African green monkey Vero cells after 7 days by MTS/PMS method	[PMID: 24800626]
Vero	CC₅₀	89 μM Compound: Chloroquine	Cytotoxicity against African green monkey Vero cells by MTS/PMS assay Cytotoxicity against African green monkey Vero cells by MTS/PMS assay	[PMID: 29499487]
Vero	CC₅₀	94.95 μM Compound: 38	Cytotoxicity against African green monkey Vero cells after 5 days by CellTiter Blue assay Cytotoxicity against African green monkey Vero cells after 5 days by CellTiter Blue assay	[PMID: 31549836]
Vero C1008	CC₅₀	> 100 μM Compound: CQ	Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition incubated for 48 hrs by CCK8 assay Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition incubated for 48 hrs by CCK8 assay	[PMID: 32771797]
Vero C1008	CC₅₀	> 100 μM Compound: CQ	Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 48 hrs by CCK-8 assay Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 48 hrs by CCK-8 assay	[PMID: 32563814]
Vero C1008	CC₅₀	> 100 μM Compound: 1	Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay	[PMID: 33486200]
Vero C1008	CC₅₀	> 100 μM Compound: 1; CQ	Cytotoxicity against African green monkey Vero E6 cells by the CCK8 assay Cytotoxicity against African green monkey Vero E6 cells by the CCK8 assay	[PMID: 32845145]
Vero C1008	CC₅₀	> 128 μM Compound: 1; CQ	Cytotoxicity against African green monkey Vero E6 cells incubated for 3 days by the MTS assay Cytotoxicity against African green monkey Vero E6 cells incubated for 3 days by the MTS assay	[PMID: 32845145]
Vero C1008	CC₅₀	249.5 μM Compound: Chloroquine	Cytotoxicity against african green monkey Vero E6 cells by CCK8 assay Cytotoxicity against african green monkey Vero E6 cells by CCK8 assay	[PMID: 33609889]
Vero C1008	CC₅₀	261 μM Compound: 1; CQ	Cytotoxicity against African green monkey Vero E6 cells by the MTS assay Cytotoxicity against African green monkey Vero E6 cells by the MTS assay	[PMID: 32845145]
Vero C1008	CC₅₀	83.4 μM Compound: CQ	Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 1 to 2 hrs by MTS colorimetric assay Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 1 to 2 hrs by MTS colorimetric assay	[PMID: 35571875]
WEHI	ED₅₀	9.7 μM Compound: 1	Cytotoxicity against mouse WEHI cell line by MTT assay Cytotoxicity against mouse WEHI cell line by MTT assay	[PMID: 16890433]
WI-38	EC₅₀	1.7 μM Compound: Chloroquine	Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay	[PMID: 17893158]
WI-38	IC₅₀	3.63 μM Compound: CQ	Cytotoxicity against human WI38 cells assessed as inhibition of proliferation after 24 hrs by SRB assay Cytotoxicity against human WI38 cells assessed as inhibition of proliferation after 24 hrs by SRB assay	[PMID: 25461309]
WI-38	CC₅₀	8.5 μM Compound: Chloroquine	Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay	[PMID: 17893158]
ZR-75-1	ED₅₀	1.2 μg/mL Compound: chloroquine	Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]

体外研究
(In Vitro)

Chloroquine (CHQ, 20 μM) 抑制 IL-12p70 释放并降低活化的人单核细胞衍生的朗格汉斯样细胞 (MoLC) 的 Th1 启动能力。
Chloroquine (20 μM) 增强 MoLC 中 IL-1 诱导的 IL-23 分泌，随后增加 CD4⁺ T 细胞释放 IL-17A^[1]。
Chloroquine (25 μM) 在亲本 MDA-MB-231 细胞中抑制常氧和缺氧条件下的 MMP-9 mRNA 表达。Chloroquine 对 MMP-2、MMP-9 和 MMP-13 mRNA 表达具有细胞、剂量和缺氧依赖性作用^[2]。
使用 IRS-954 或 Chloroquine 抑制 TLR7 和 TLR9 在体外显著降低 HuH7 细胞增殖^[3]。
Chloroquine (0.01-100 μM；48 小时) 有效阻断病毒感染 vero E6 细胞，抑制 SARS-CoV-2 感染具有低微摩尔浓度 (EC₅₀=1.13 μM)。
Chloroquine 通过增加病毒/细胞融合所需的内体 pH 值以及干扰 SARS-CoV 细胞受体的糖基化来阻断病毒感染^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Chloroquine (80 mg/kg，ip) 不会阻止原位小鼠模型中具有高或低 TLR9 表达水平的三阴性 MDA-MB-231 细胞的生长^[2]。
使用 IRS-954 或 Chloroquine 抑制 TLR7 和 TLR9 可显著抑制小鼠异种移植模型中的肿瘤生长。Chloroquine也显著抑制了 DEN/NMOR 大鼠模型中 HCC 的发展^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

319.87

Formula

C₁₈H₂₆ClN₃

CAS 号

54-05-7

性状

固体

颜色

White to light yellow

中文名称

氯喹

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

细胞实验：

Ethanol 中的溶解度 : 100 mg/mL (312.63 mM; 超声助溶)

DMSO 中的溶解度 : 50 mg/mL (156.31 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1263 mL	15.6314 mL	31.2627 mL
5 mM	0.6253 mL	3.1263 mL	6.2525 mL
10 mM	0.3126 mL	1.5631 mL	3.1263 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.82 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.82 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.82 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： 50% PEG300 50% Saline
Solubility: 10 mg/mL (31.26 mM); 悬浊液; Need ultrasonic and warming and heat to 44°C

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.82%

选择批次：

Data Sheet (642 KB) SDS (393 KB)

COA (281 KB) HNMR (252 KB) LCMS (92 KB) 元素分析报告 (205 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43. [Content Brief]

[2]. Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672. [Content Brief]

[3]. Mohamed FE, et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626. [Content Brief]

[4]. Colson P, et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020;55(4):105932. [Content Brief]

[5]. Savarino A, et al. The anti-HIV-1 activity of chloroquine. J Clin Virol. 2001;20(3):131-135. [Content Brief]

Chloroquine 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol	1 mM	3.1263 mL	15.6314 mL	31.2627 mL	78.1568 mL
	5 mM	0.6253 mL	3.1263 mL	6.2525 mL	15.6314 mL
	10 mM	0.3126 mL	1.5631 mL	3.1263 mL	7.8157 mL
	15 mM	0.2084 mL	1.0421 mL	2.0842 mL	5.2105 mL
	20 mM	0.1563 mL	0.7816 mL	1.5631 mL	3.9078 mL
	25 mM	0.1251 mL	0.6253 mL	1.2505 mL	3.1263 mL
	30 mM	0.1042 mL	0.5210 mL	1.0421 mL	2.6052 mL
	40 mM	0.0782 mL	0.3908 mL	0.7816 mL	1.9539 mL
	50 mM	0.0625 mL	0.3126 mL	0.6253 mL	1.5631 mL
	60 mM	0.0521 mL	0.2605 mL	0.5210 mL	1.3026 mL
	80 mM	0.0391 mL	0.1954 mL	0.3908 mL	0.9770 mL
	100 mM	0.0313 mL	0.1563 mL	0.3126 mL	0.7816 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Chloroquine (Synonyms: 氯喹)

Customer Review

Other Forms of Chloroquine:

MCE 顾客使用本产品发表的 668 篇科研文献

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Chloroquine (Synonyms: 氯喹)

Customer Review

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