2. Academic Validation
  3. Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation

Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation

  • Adv Sci (Weinh). 2023 Dec 12:e2305620. doi: 10.1002/advs.202305620.
Huan Li 1,  Chao Song 1,  Yang Zhang 1,  Guohao Liu 2,  Hailong Mi 1,  Yachao Li 1,  Zhiye Chen 2,  Xiaoyu Ma 2,  Po Zhang 2,  Lidong Cheng 2,  Peng Peng 2,  Hongtao Zhu 2,  Zirong Chen 2,  Minhai Dong 2,  Sui Chen 2,  Hao Meng 3,  QunGen Xiao 2,  Honglian Li 1,  Qiulian Wu 4,  Baofeng Wang 2,  Suojun Zhang 2,  Kai Shu 2,  Feng Wan 2,  Dongsheng Guo 2,  Wenchao Zhou 3,  Lin Zhou 1,  Feng Mao 2,  Jeremy N Rich 4 5,  Xingjiang Yu 1
Affiliations

Affiliations

  • 1 Department of Histology and Embryology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • 2 Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • 3 Intelligent Pathology Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230031, China.
  • 4 UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, 15219, USA.
  • 5 Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
PMID: 38087889 DOI: 10.1002/advs.202305620
Abstract

Glioblastoma (GBM) is a lethal Cancer characterized by hypervascularity and necrosis associated with hypoxia. Here, it is found that hypoxia preferentially induces the actin-binding protein, Transgelin (TAGLN), in GBM stem cells (GSCs). Mechanistically, TAGLN regulates HIF1α transcription and stabilizes HDAC2 to deacetylate p53 and maintain GSC self-renewal. To translate these findings into preclinical therapeutic paradigm, it is found that sodium valproate (VPA) is a specific inhibitor of TAGLN/HDAC2 function, with augmented efficacy when combined with natural borneol (NB) in vivo. Thus, TAGLN promotes Cancer stem cell survival in hypoxia and informs a novel therapeutic paradigm.

Keywords

HDAC2; HIF1α Hypoxia; glioblastoma stem cells; natural borneol; sodium valproate; transgelin.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z