2. Academic Validation
  3. Synthesis and antiprotozoal activity of 4-arylcoumarins

Synthesis and antiprotozoal activity of 4-arylcoumarins

  • Eur J Med Chem. 2010 Mar;45(3):864-9. doi: 10.1016/j.ejmech.2009.10.022.
Jean-Thomas Pierson 1,  Aurélien Dumètre,  Sébastien Hutter,  Florence Delmas,  Michèle Laget,  Jean-Pierre Finet,  Nadine Azas,  Sébastien Combes
Affiliations

Affiliation

  • 1 Faculté des Sciences de Saint-Jérôme, UMR-CNRS 6264, Laboratoire Chimie Provence, Universités Aix-Marseille I, II and III, 13397 Marseille Cedex 20, France.
PMID: 19914747 DOI: 10.1016/j.ejmech.2009.10.022
Abstract

A large series of 4-arylcoumarins was synthesized by Suzuki-Miyaura cross-coupling reaction and evaluated for antiprotozoal activity against Plasmodium falciparum and Leishmania donovani. Several compounds were found to strongly inhibit the proliferation of human cell line and/or parasites. The 4-(3,4-dimethoxyphenyl)-6,7-dimethoxycoumarin exhibit a potent activity on L. donovani amastigotes with a selectivity index (SI=265) twice than amphotericin B (SI=140).

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z